Diazepam Reinforcement in Anxious Patients

Diazepam Reinforcement in Anxious Patients

The reinforcing effects of diazepam were examined in 4 female patients with generalized anxiety disorder but without histories of drug abuse. Under double-blind conditions, patients were given medication capsules containing either 4 mg diazepam or placebo that they could use "as needed" fo...

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Veröffentlicht in:Experimental and clinical psychopharmacology 1996-08, Vol.4 (3), p.308-314
Hauptverfasser: Roache, John D, Stanley, Melinda A, Creson, Daniel L, Meisch, Richard A, Shah, Nurun N
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Anxiety Disorders
Diazepam
Drug Therapy
Female
Human
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container_issue 3
container_start_page 308
container_title Experimental and clinical psychopharmacology
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creator Roache, John D
Stanley, Melinda A
Creson, Daniel L
Meisch, Richard A
Shah, Nurun N
description The reinforcing effects of diazepam were examined in 4 female patients with generalized anxiety disorder but without histories of drug abuse. Under double-blind conditions, patients were given medication capsules containing either 4 mg diazepam or placebo that they could use "as needed" for anxiety. After a 1-week sampling period for each medication, participants repeatedly chose which medication they preferred over the next 4 weeks. Reinforcing effects of diazepam were demonstrated in 3 participants who showed exclusive diazepam preference. The results suggest procedures whereby drug self-medication behavior may be studied in an outpatient environment.
doi_str_mv 10.1037/1064-1297.4.3.308
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subjects Anxiety Disorders
Diazepam
Drug Therapy
Female
Human
title Diazepam Reinforcement in Anxious Patients
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