Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring
This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring betwee...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia bulletin 2000-01, Vol.26 (2), p.275-286 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 286 |
|---|---|
| container_issue | 2 |
| container_start_page | 275 |
| container_title | Schizophrenia bulletin |
| container_volume | 26 |
| creator | Schaefer, Catherine A Brown, Alan S Wyatt, Richard Jed Kline, Jennie Begg, Melissa D Bresnahan, Michaeline A Susser, Ezra S |
| description | This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to women enrolled in a prepaid health plan. Computerized treatment registries were used to identify possible cases of schizophrenia and spectrum disorders in adult offspring belonging to the health plan from 1981 to 1997. Diagnostic interviews and medical record reviews resulted in diagnosis of 63 cases of schizophrenia and spectrum disorders; these cases and 6,570 unrelated and unaffected cohort members whose mothers also had prepregnancy measures of BMI comprised the sample for analyses. High (≥ 30.0), compared with average (20.0-26.9), maternal prepregnant BMI (kg/m2) was significantly associated with schizophrenia and spectrum disorders in the adult offspring (relative risk [RR] = 2.9; 95% confidence interval [CI] 1.3-6.6), independently of maternal age, parity, race, education, or cigarette smoking during pregnancy. Low (≤ 19.9) maternal BMI was not associated with schizophrenia and spectrum disorders (RR = 1.2; 95% CI 0.64-2.2). Future studies of this cohort will examine factors that may help explain the relationship of high maternal prepregnant BMI with schizophrenia, including nutritional and metabolic factors, toxic exposures, and obstetrical complications. |
| doi_str_mv | 10.1093/oxfordjournals.schbul.a033452 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_614336851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>614336851</sourcerecordid><originalsourceid>FETCH-LOGICAL-a495t-6a2c2260f5f64bc92e5c1a1a676a2715deb40bc2160b6ddbf123dda327e9ec563</originalsourceid><addsrcrecordid>eNp9kEtP3DAURq0KVKbQv1BZCFYog99JFl0AogUBAkG7tm78YEJDEuxEYubX16MMot2wuot7vvs4CB1SMqek5Mfdq--CferG0EIT59EsqrGZA-FcSPYJzWguZEZzQrfQjMhCZbmiYgd9ifGJECpKxT6jHUqKQipOZujqBga3HoXvguuDe2yhHfBpZ5f4BmLE0Fp8X8c_uPP4wSzqVdcvgmtrwHWLT-zYDPjW-9iHun3cQ9s-3eS-buou-v3j_NfZRXZ9-_Py7OQ6A1HKIVPADGOKeOmVqEzJnDQUKKg8dXIqrasEqQyjilTK2spTxq0FznJXOpPO3kX709w-dC-ji4N-06HTr5yrQtKPIMa4FEpwlqDvE2RCF2NwXqdHniEsNSV6rVv_r1tPuvVGd8p_2ywZq2dn_0lPfhNwsAEgGmh8gNbU8Z0TpOBMJOxowqAH3celgTDUpnHRjCHZHnRcVZopzTTLJf8L2UyfNA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>614336851</pqid></control><display><type>article</type><title>Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring</title><source>Oxford University Press Journals</source><source>MEDLINE</source><source>PsycARTICLES</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Schaefer, Catherine A ; Brown, Alan S ; Wyatt, Richard Jed ; Kline, Jennie ; Begg, Melissa D ; Bresnahan, Michaeline A ; Susser, Ezra S</creator><creatorcontrib>Schaefer, Catherine A ; Brown, Alan S ; Wyatt, Richard Jed ; Kline, Jennie ; Begg, Melissa D ; Bresnahan, Michaeline A ; Susser, Ezra S</creatorcontrib><description>This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to women enrolled in a prepaid health plan. Computerized treatment registries were used to identify possible cases of schizophrenia and spectrum disorders in adult offspring belonging to the health plan from 1981 to 1997. Diagnostic interviews and medical record reviews resulted in diagnosis of 63 cases of schizophrenia and spectrum disorders; these cases and 6,570 unrelated and unaffected cohort members whose mothers also had prepregnancy measures of BMI comprised the sample for analyses. High (≥ 30.0), compared with average (20.0-26.9), maternal prepregnant BMI (kg/m2) was significantly associated with schizophrenia and spectrum disorders in the adult offspring (relative risk [RR] = 2.9; 95% confidence interval [CI] 1.3-6.6), independently of maternal age, parity, race, education, or cigarette smoking during pregnancy. Low (≤ 19.9) maternal BMI was not associated with schizophrenia and spectrum disorders (RR = 1.2; 95% CI 0.64-2.2). Future studies of this cohort will examine factors that may help explain the relationship of high maternal prepregnant BMI with schizophrenia, including nutritional and metabolic factors, toxic exposures, and obstetrical complications.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/oxfordjournals.schbul.a033452</identifier><identifier>PMID: 10885630</identifier><identifier>CODEN: SCZBB3</identifier><language>eng</language><publisher>Oxford: National Institute of Mental Health</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Body Mass Index ; Body Weight ; Cohort Studies ; Diseases of mother, fetus and pregnancy ; Etiology ; Female ; Gynecology. Andrology. Obstetrics ; Human ; Humans ; Male ; Maternal Welfare ; Medical sciences ; Offspring ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prenatal Exposure Delayed Effects ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Risk Assessment ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - etiology</subject><ispartof>Schizophrenia bulletin, 2000-01, Vol.26 (2), p.275-286</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Superintendent of Documents 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a495t-6a2c2260f5f64bc92e5c1a1a676a2715deb40bc2160b6ddbf123dda327e9ec563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1408324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10885630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaefer, Catherine A</creatorcontrib><creatorcontrib>Brown, Alan S</creatorcontrib><creatorcontrib>Wyatt, Richard Jed</creatorcontrib><creatorcontrib>Kline, Jennie</creatorcontrib><creatorcontrib>Begg, Melissa D</creatorcontrib><creatorcontrib>Bresnahan, Michaeline A</creatorcontrib><creatorcontrib>Susser, Ezra S</creatorcontrib><title>Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to women enrolled in a prepaid health plan. Computerized treatment registries were used to identify possible cases of schizophrenia and spectrum disorders in adult offspring belonging to the health plan from 1981 to 1997. Diagnostic interviews and medical record reviews resulted in diagnosis of 63 cases of schizophrenia and spectrum disorders; these cases and 6,570 unrelated and unaffected cohort members whose mothers also had prepregnancy measures of BMI comprised the sample for analyses. High (≥ 30.0), compared with average (20.0-26.9), maternal prepregnant BMI (kg/m2) was significantly associated with schizophrenia and spectrum disorders in the adult offspring (relative risk [RR] = 2.9; 95% confidence interval [CI] 1.3-6.6), independently of maternal age, parity, race, education, or cigarette smoking during pregnancy. Low (≤ 19.9) maternal BMI was not associated with schizophrenia and spectrum disorders (RR = 1.2; 95% CI 0.64-2.2). Future studies of this cohort will examine factors that may help explain the relationship of high maternal prepregnant BMI with schizophrenia, including nutritional and metabolic factors, toxic exposures, and obstetrical complications.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Cohort Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Etiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Maternal Welfare</subject><subject>Medical sciences</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Risk Assessment</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - etiology</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAURq0KVKbQv1BZCFYog99JFl0AogUBAkG7tm78YEJDEuxEYubX16MMot2wuot7vvs4CB1SMqek5Mfdq--CferG0EIT59EsqrGZA-FcSPYJzWguZEZzQrfQjMhCZbmiYgd9ifGJECpKxT6jHUqKQipOZujqBga3HoXvguuDe2yhHfBpZ5f4BmLE0Fp8X8c_uPP4wSzqVdcvgmtrwHWLT-zYDPjW-9iHun3cQ9s-3eS-buou-v3j_NfZRXZ9-_Py7OQ6A1HKIVPADGOKeOmVqEzJnDQUKKg8dXIqrasEqQyjilTK2spTxq0FznJXOpPO3kX709w-dC-ji4N-06HTr5yrQtKPIMa4FEpwlqDvE2RCF2NwXqdHniEsNSV6rVv_r1tPuvVGd8p_2ywZq2dn_0lPfhNwsAEgGmh8gNbU8Z0TpOBMJOxowqAH3celgTDUpnHRjCHZHnRcVZopzTTLJf8L2UyfNA</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Schaefer, Catherine A</creator><creator>Brown, Alan S</creator><creator>Wyatt, Richard Jed</creator><creator>Kline, Jennie</creator><creator>Begg, Melissa D</creator><creator>Bresnahan, Michaeline A</creator><creator>Susser, Ezra S</creator><general>National Institute of Mental Health</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7RZ</scope><scope>PSYQQ</scope></search><sort><creationdate>20000101</creationdate><title>Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring</title><author>Schaefer, Catherine A ; Brown, Alan S ; Wyatt, Richard Jed ; Kline, Jennie ; Begg, Melissa D ; Bresnahan, Michaeline A ; Susser, Ezra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a495t-6a2c2260f5f64bc92e5c1a1a676a2715deb40bc2160b6ddbf123dda327e9ec563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Cohort Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Etiology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Maternal Welfare</topic><topic>Medical sciences</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Risk Assessment</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaefer, Catherine A</creatorcontrib><creatorcontrib>Brown, Alan S</creatorcontrib><creatorcontrib>Wyatt, Richard Jed</creatorcontrib><creatorcontrib>Kline, Jennie</creatorcontrib><creatorcontrib>Begg, Melissa D</creatorcontrib><creatorcontrib>Bresnahan, Michaeline A</creatorcontrib><creatorcontrib>Susser, Ezra S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaefer, Catherine A</au><au>Brown, Alan S</au><au>Wyatt, Richard Jed</au><au>Kline, Jennie</au><au>Begg, Melissa D</au><au>Bresnahan, Michaeline A</au><au>Susser, Ezra S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>26</volume><issue>2</issue><spage>275</spage><epage>286</epage><pages>275-286</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><coden>SCZBB3</coden><abstract>This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to women enrolled in a prepaid health plan. Computerized treatment registries were used to identify possible cases of schizophrenia and spectrum disorders in adult offspring belonging to the health plan from 1981 to 1997. Diagnostic interviews and medical record reviews resulted in diagnosis of 63 cases of schizophrenia and spectrum disorders; these cases and 6,570 unrelated and unaffected cohort members whose mothers also had prepregnancy measures of BMI comprised the sample for analyses. High (≥ 30.0), compared with average (20.0-26.9), maternal prepregnant BMI (kg/m2) was significantly associated with schizophrenia and spectrum disorders in the adult offspring (relative risk [RR] = 2.9; 95% confidence interval [CI] 1.3-6.6), independently of maternal age, parity, race, education, or cigarette smoking during pregnancy. Low (≤ 19.9) maternal BMI was not associated with schizophrenia and spectrum disorders (RR = 1.2; 95% CI 0.64-2.2). Future studies of this cohort will examine factors that may help explain the relationship of high maternal prepregnant BMI with schizophrenia, including nutritional and metabolic factors, toxic exposures, and obstetrical complications.</abstract><cop>Oxford</cop><pub>National Institute of Mental Health</pub><pmid>10885630</pmid><doi>10.1093/oxfordjournals.schbul.a033452</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0586-7614 |
| ispartof | Schizophrenia bulletin, 2000-01, Vol.26 (2), p.275-286 |
| issn | 0586-7614 1745-1701 |
| language | eng |
| recordid | cdi_proquest_journals_614336851 |
| source | Oxford University Press Journals; MEDLINE; PsycARTICLES; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Body Mass Index Body Weight Cohort Studies Diseases of mother, fetus and pregnancy Etiology Female Gynecology. Andrology. Obstetrics Human Humans Male Maternal Welfare Medical sciences Offspring Pregnancy Pregnancy. Fetus. Placenta Prenatal Exposure Delayed Effects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Risk Assessment Schizophrenia Schizophrenia - epidemiology Schizophrenia - etiology |
| title | Maternal Prepregnant Body Mass and Risk of Schizophrenia in Adult Offspring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T19%3A05%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20Prepregnant%20Body%20Mass%20and%20Risk%20of%20Schizophrenia%20in%20Adult%20Offspring&rft.jtitle=Schizophrenia%20bulletin&rft.au=Schaefer,%20Catherine%20A&rft.date=2000-01-01&rft.volume=26&rft.issue=2&rft.spage=275&rft.epage=286&rft.pages=275-286&rft.issn=0586-7614&rft.eissn=1745-1701&rft.coden=SCZBB3&rft_id=info:doi/10.1093/oxfordjournals.schbul.a033452&rft_dat=%3Cproquest_cross%3E614336851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=614336851&rft_id=info:pmid/10885630&rfr_iscdi=true |