Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. An updated analysis considering smoking as the main confounding factor
A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (D...
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| Veröffentlicht in: | Radiation and environmental biophysics 2003-07, Vol.42 (2), p.129 |
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| creator | Kreisheimer, M Sokolnikov, M E Koshurnikova, N A Khokhryakov, V F Romanow, S A Shilnikova, N S Okatenko, P V Nekolla, E A Kellerer, A M |
| description | A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5). |
| doi_str_mv | 10.1007/s00411-003-0198-3 |
| format | Article |
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An updated analysis considering smoking as the main confounding factor</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kreisheimer, M ; Sokolnikov, M E ; Koshurnikova, N A ; Khokhryakov, V F ; Romanow, S A ; Shilnikova, N S ; Okatenko, P V ; Nekolla, E A ; Kellerer, A M</creator><creatorcontrib>Kreisheimer, M ; Sokolnikov, M E ; Koshurnikova, N A ; Khokhryakov, V F ; Romanow, S A ; Shilnikova, N S ; Okatenko, P V ; Nekolla, E A ; Kellerer, A M</creatorcontrib><description>A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5).</description><identifier>ISSN: 0301-634X</identifier><identifier>EISSN: 1432-2099</identifier><identifier>DOI: 10.1007/s00411-003-0198-3</identifier><identifier>PMID: 12851829</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Cancer ; Cohort Studies ; Confounding Factors, Epidemiologic ; Dose-Response Relationship, Radiation ; Dosimetry ; Humans ; Lung cancer ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Lung Neoplasms - mortality ; Male ; Models, Statistical ; Mortality ; Neoplasms, Radiation-Induced - mortality ; Nuclear Reactors ; Occupational Diseases - epidemiology ; Occupational Diseases - mortality ; Occupational exposure ; Occupational Exposure - adverse effects ; Plutonium ; Plutonium - adverse effects ; Risk Assessment ; Russia ; Smoking</subject><ispartof>Radiation and environmental biophysics, 2003-07, Vol.42 (2), p.129</ispartof><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12851829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kreisheimer, M</creatorcontrib><creatorcontrib>Sokolnikov, M E</creatorcontrib><creatorcontrib>Koshurnikova, N A</creatorcontrib><creatorcontrib>Khokhryakov, V F</creatorcontrib><creatorcontrib>Romanow, S A</creatorcontrib><creatorcontrib>Shilnikova, N S</creatorcontrib><creatorcontrib>Okatenko, P V</creatorcontrib><creatorcontrib>Nekolla, E A</creatorcontrib><creatorcontrib>Kellerer, A M</creatorcontrib><title>Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. An updated analysis considering smoking as the main confounding factor</title><title>Radiation and environmental biophysics</title><addtitle>Radiat Environ Biophys</addtitle><description>A new analysis of lung cancer mortality in a cohort of male Mayak workers who started their employment in the plutonium and reprocessing plants between 1948 and 1958 has been carried out in terms of a relative risk model. The follow-up has been extended until 1999, moreover a new dosimetry system (DOSES2000) has been established. Particular emphasis has been given to a discrimination of the effects of external gamma-exposure and internal alpha-exposure due to incorporated plutonium. This study has also utilized and incorporated the information from a cohort of Mayak reactor workers, who were exposed only externally to gamma-rays. The influence of smoking as the main confounding factor for lung cancer has been studied. The baseline lung cancer mortality rate was not taken from national statistics but was derived from the cohort itself. The estimated excess relative risk for the plutonium alpha-rays was 0.23/Sv (95%CI: 0.16-0.31). The resulting risk coefficient for external gamma-ray exposure was very low with a statistically insignificant estimate of 0.058/Sv (95%CI: -0.072-0.20). The inferred relative risk for smokers was 16.5 (95%CI: 12.6-20.5).</description><subject>Cancer</subject><subject>Cohort Studies</subject><subject>Confounding Factors, Epidemiologic</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Dosimetry</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Models, Statistical</subject><subject>Mortality</subject><subject>Neoplasms, Radiation-Induced - mortality</subject><subject>Nuclear Reactors</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - mortality</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - adverse effects</subject><subject>Plutonium</subject><subject>Plutonium - adverse effects</subject><subject>Risk Assessment</subject><subject>Russia</subject><subject>Smoking</subject><issn>0301-634X</issn><issn>1432-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo1kM1OwzAQhC0EglJ4AC7I4p6ytlMnPlYVf1IRB0DiVm0cB0wbu9gJKC_Ec2JKuexIs6NvVkvIGYMJAyguI0DOWAYgMmCqzMQeGbFc8IyDUvtkBAJYJkX-ckSOY3wHYIWU6pAcMV5OWcnViHwvevdKNTptAm196HBtu4Fi65Pter02GOiXDysTIvUN7d4MvccBV7RBbVPWmkit2_qND22iPPpPazr67Kx3EzpztN_U2JmaosP1EG2k2rtoaxNs6oitX_0qxi2jxQRL-8b3rv71U03nwwk5aHAdzelOx-T5-uppfpstHm7u5rNFtuEi77KqAuA5SllVmoNRjZyqqq6kEQWKWpoSVcFrkKUGZUrNpeFpctUUggldgRiTiz_uJviP3sRu-e77kO6OS8nEtBC8UCl0vgv1VWvq5SbYFsOw_P-q-AFAjn0j</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Kreisheimer, M</creator><creator>Sokolnikov, M E</creator><creator>Koshurnikova, N A</creator><creator>Khokhryakov, V F</creator><creator>Romanow, S A</creator><creator>Shilnikova, N S</creator><creator>Okatenko, P V</creator><creator>Nekolla, E A</creator><creator>Kellerer, A M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7ST</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope></search><sort><creationdate>20030701</creationdate><title>Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. 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| subjects | Cancer Cohort Studies Confounding Factors, Epidemiologic Dose-Response Relationship, Radiation Dosimetry Humans Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - etiology Lung Neoplasms - mortality Male Models, Statistical Mortality Neoplasms, Radiation-Induced - mortality Nuclear Reactors Occupational Diseases - epidemiology Occupational Diseases - mortality Occupational exposure Occupational Exposure - adverse effects Plutonium Plutonium - adverse effects Risk Assessment Russia Smoking |
| title | Lung cancer mortality among nuclear workers of the Mayak facilities in the former Soviet Union. An updated analysis considering smoking as the main confounding factor |
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