Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function

Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function

To study trough levels of metformin in serum and its intra-individual variation in patients using a newly developed assay. Trough serum levels of metformin were measured once using liquid chromatography-tandem mass spectrometry (LCMSMS) in 137 type 2 diabetic patients with varying renal function (99...

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Veröffentlicht in:Diabetes care 2010-06, Vol.33 (6), p.1291-1293
Hauptverfasser: Frid, Anders, Sterner, Gunnar N., Löndahl, Magnus, Wiklander, Clara, Cato, Anne, Vinge, Ellen, Andersson, Anders
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Chromatography
Clinical medicine
Diabetes
Studies
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container_end_page 1293
container_issue 6
container_start_page 1291
container_title Diabetes care
container_volume 33
creator Frid, Anders
Sterner, Gunnar N.
Löndahl, Magnus
Wiklander, Clara
Cato, Anne
Vinge, Ellen
Andersson, Anders
description To study trough levels of metformin in serum and its intra-individual variation in patients using a newly developed assay. Trough serum levels of metformin were measured once using liquid chromatography-tandem mass spectrometry (LCMSMS) in 137 type 2 diabetic patients with varying renal function (99 men) and followed repeatedly during 2 months in 20 patients (16 men) with estimated glomerular filtration rate (eGFR) 60, 30-60, and 20 µmol/l. Metformin measurement is less suitable for dose titration.
doi_str_mv 10.2337/dc09-1284
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subjects Chromatography
Clinical medicine
Diabetes
Studies
title Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function
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