Primary hypertension at a single center: treatment, time to control, and extended follow-up
We present data on presentation, treatment, and follow-up of 65 pediatric patients with primary hypertension treated over the past 12 years, including initial anthropometric data, pharmacologic treatment, time to control for both systolic and diastolic blood pressure (SBP/DBP), and maintenance of co...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2009-12, Vol.24 (12), p.2421-2428 |
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| creator | DiPietro, Amy Kees-Folts, Deborah DesHarnais, Susan Camacho, Fabian Wassner, Steven Joel |
| description | We present data on presentation, treatment, and follow-up of 65 pediatric patients with primary hypertension treated over the past 12 years, including initial anthropometric data, pharmacologic treatment, time to control for both systolic and diastolic blood pressure (SBP/DBP), and maintenance of control over time. Data was normalized to standard deviation scores (SDS) for mathematical analysis, and antihypertensive medication dosages were converted to dosage equivalents for a single member of each antihypertensive class. We used multiple regression analysis and Kaplan-Meier survival curves to determine the time to control, medication, and dose effectiveness. Patients were seen for an average of seven visits over 25 months. Initial BPs averaged 134/71 mmHg (2.1/0.6 SDS). Patients were taller, heavier, and had higher body mass index than average for age and sex. By the fourth visit, SBP was |
| doi_str_mv | 10.1007/s00467-009-1297-4 |
| format | Article |
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Data was normalized to standard deviation scores (SDS) for mathematical analysis, and antihypertensive medication dosages were converted to dosage equivalents for a single member of each antihypertensive class. We used multiple regression analysis and Kaplan-Meier survival curves to determine the time to control, medication, and dose effectiveness. Patients were seen for an average of seven visits over 25 months. Initial BPs averaged 134/71 mmHg (2.1/0.6 SDS). Patients were taller, heavier, and had higher body mass index than average for age and sex. By the fourth visit, SBP was <90th percentile in 79%. Ninety percent could be controlled, although 32 lost control at some point (at least 16 due to noncompliance). At the last visit, 46 were controlled, and 5/8 patients off medication remained normotensive. Only angiotensin-converting enzyme inhibitors and β-blockers demonstrated significant association with BP control. 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Data was normalized to standard deviation scores (SDS) for mathematical analysis, and antihypertensive medication dosages were converted to dosage equivalents for a single member of each antihypertensive class. We used multiple regression analysis and Kaplan-Meier survival curves to determine the time to control, medication, and dose effectiveness. Patients were seen for an average of seven visits over 25 months. Initial BPs averaged 134/71 mmHg (2.1/0.6 SDS). Patients were taller, heavier, and had higher body mass index than average for age and sex. By the fourth visit, SBP was <90th percentile in 79%. Ninety percent could be controlled, although 32 lost control at some point (at least 16 due to noncompliance). At the last visit, 46 were controlled, and 5/8 patients off medication remained normotensive. Only angiotensin-converting enzyme inhibitors and β-blockers demonstrated significant association with BP control. 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drug therapy</subject><subject>Medical diagnosis</subject><subject>Medical referrals</subject><subject>Medication Adherence</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Patient Compliance</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Primary Health Care</subject><subject>Systole</subject><subject>Teenagers</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urology</subject><subject>Weight control</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc9rHCEUx6W0NNu0f0AvRXroKSY6zvq0txDSHxBoDi0EehB35rk7YUa36tDkv69hFtJCigdRP9_38H0IeSv4qeAczjLnrQLGuWGiMcDaZ2QlWtkwYfTNc7LiRgrGW3FzRF7lfMs512utXpIjYaByClbk53UaJpfu6e5-j6lgyEMM1BXqaB7CdkTaYSiYPtKS0JWpHk5oGSakJdIuhpLieEJd6Cne1XSPPfVxHONvNu9fkxfejRnfHPZj8uPT5feLL-zq2-evF-dXrGtBFya09J2S3CiUuumN6DQ0agNr7hvQHnrX6J5Dq8QGNhylBNMqL5xwvgcAI4_J-6XuPsVfM-Zib-OcQm1p16ClEkqsK8QWaOtGtEPwsSTXbTFgcmMM6Id6fS61aoUCBZU_fYKvq8dp6J4MfPgrsEM3ll2O41zqQPO_oFjALsWcE3q7XxxYwe2DV7t4tdWrffBq25p5d_jivJmwf0wcRFagWYBcn8IW0-MM_l_1Dzf6q3E</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>DiPietro, Amy</creator><creator>Kees-Folts, Deborah</creator><creator>DesHarnais, Susan</creator><creator>Camacho, Fabian</creator><creator>Wassner, Steven Joel</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20091201</creationdate><title>Primary hypertension at a single center: treatment, time to control, and extended follow-up</title><author>DiPietro, Amy ; Kees-Folts, Deborah ; DesHarnais, Susan ; Camacho, Fabian ; Wassner, Steven Joel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-183fc63096e382d91c8726b750f278f7da28d07461b7b0e337946f1a1afd77793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenergic beta-Antagonists - 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Data was normalized to standard deviation scores (SDS) for mathematical analysis, and antihypertensive medication dosages were converted to dosage equivalents for a single member of each antihypertensive class. We used multiple regression analysis and Kaplan-Meier survival curves to determine the time to control, medication, and dose effectiveness. Patients were seen for an average of seven visits over 25 months. Initial BPs averaged 134/71 mmHg (2.1/0.6 SDS). Patients were taller, heavier, and had higher body mass index than average for age and sex. By the fourth visit, SBP was <90th percentile in 79%. Ninety percent could be controlled, although 32 lost control at some point (at least 16 due to noncompliance). At the last visit, 46 were controlled, and 5/8 patients off medication remained normotensive. Only angiotensin-converting enzyme inhibitors and β-blockers demonstrated significant association with BP control. This is the first study to document the time to control of BP, and it can serve as an initial standard for quality assessment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>19714367</pmid><doi>10.1007/s00467-009-1297-4</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2009-12, Vol.24 (12), p.2421-2428 |
| issn | 0931-041X 1432-198X |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adrenergic beta-Antagonists - therapeutic use Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Antihypertensives Blood Pressure - drug effects Blood Pressure - physiology Body mass index Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - therapeutic use Child Dose-Response Relationship, Drug Enzymes Follow-Up Studies Humans Hypertension Hypertension - drug therapy Medical diagnosis Medical referrals Medication Adherence Medicine & Public Health Nephrology Obesity Original Article Patient Compliance Patients Pediatrics Primary Health Care Systole Teenagers Time Factors Treatment Outcome Urology Weight control |
| title | Primary hypertension at a single center: treatment, time to control, and extended follow-up |
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