Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro

The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synth...

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Veröffentlicht in:	Physiological research 2010-01, Vol.59 (2), p.225-232
Hauptverfasser:	Rousar, T, Pařík, P, Kucera, O, Bartos, M, Červinková, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - chemical synthesis Acetaminophen - toxicity Analgesics, Non-Narcotic - chemical synthesis Analgesics, Non-Narcotic - toxicity Animals Apoptosis Cells, Cultured Dose-Response Relationship, Drug Drug Combinations Enzyme Activation - drug effects Glutathione - chemical synthesis Glutathione - toxicity Glutathione Reductase - antagonists & inhibitors Glutathione Reductase - metabolism Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - pathology In Vitro Techniques Liver Male Metabolites Rats Rats, Wistar Rodents Toxicity
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