Liver histology and HBV DNA levels in chronically HBV infected patients with persistently normal alanine aminotransferase
Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients. There were 132 patients with HBeAg negative chronic HBV...
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| Veröffentlicht in: | Archives of Iranian medicine 2010-05, Vol.13 (3), p.193 |
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| creator | Montazeri, Ghodrate Rahban, Maryam Mohamadnejad, Mehdi Zamani, Farhad Hooshyar, Afshin Fazlolahi, Atoosa Abedian, Shifteh Ghoujeghi, Farhad Estakhri, Arezoo Montazeri, Farhad Razjoyan, Hadi Mamarabadi, Mansoureh Alimohamadi, Meysam Tavangar, Seyed Mohamad Malekzadeh, Reza |
| description | Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients.
There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed.
A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score > or = 5, 53 cases (40.2%) had grade > or = 4 and 40 cases (30.3%) had stage > or = 2. A baseline HBV DNA or = 5, 28 cases (53%) of those with grade > or = 4 and 9 cases (22.5%) with stage > or = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by > or = 2 scores and the HBV DNA of 18 cases (22.5%) increased by > or = 1 Log10 IU when compared to baseline values.
HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL. |
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There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed.
A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score > or = 5, 53 cases (40.2%) had grade > or = 4 and 40 cases (30.3%) had stage > or = 2. A baseline HBV DNA <2000 IU/mL was seen in 24 cases (48%) of those with total score > or = 5, 28 cases (53%) of those with grade > or = 4 and 9 cases (22.5%) with stage > or = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by > or = 2 scores and the HBV DNA of 18 cases (22.5%) increased by > or = 1 Log10 IU when compared to baseline values.
HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL.</description><identifier>ISSN: 1029-2977</identifier><identifier>EISSN: 1735-3947</identifier><identifier>PMID: 20433223</identifier><language>eng</language><publisher>Iran: Academy of Medical Sciences of I.R. Iran</publisher><subject>Adult ; Age Factors ; Aged ; Alanine Transaminase - blood ; Analysis of Variance ; Biopsy, Needle ; Cohort Studies ; DNA, Viral - analysis ; Follow-Up Studies ; Hepatitis B e Antigens - blood ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - enzymology ; Hepatitis B, Chronic - pathology ; Humans ; Immunohistochemistry ; Linear Models ; Liver Function Tests ; Male ; Middle Aged ; Monitoring, Physiologic - methods ; Multivariate Analysis ; Reference Values ; Retrospective Studies ; Risk Assessment ; ROC Curve ; Sensitivity and Specificity ; Severity of Illness Index ; Time Factors</subject><ispartof>Archives of Iranian medicine, 2010-05, Vol.13 (3), p.193</ispartof><rights>Copyright Dr Ali Akbari Sari, Director of The Commission for Accreditation & Improvement of Iranian Medical Journals May 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20433223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montazeri, Ghodrate</creatorcontrib><creatorcontrib>Rahban, Maryam</creatorcontrib><creatorcontrib>Mohamadnejad, Mehdi</creatorcontrib><creatorcontrib>Zamani, Farhad</creatorcontrib><creatorcontrib>Hooshyar, Afshin</creatorcontrib><creatorcontrib>Fazlolahi, Atoosa</creatorcontrib><creatorcontrib>Abedian, Shifteh</creatorcontrib><creatorcontrib>Ghoujeghi, Farhad</creatorcontrib><creatorcontrib>Estakhri, Arezoo</creatorcontrib><creatorcontrib>Montazeri, Farhad</creatorcontrib><creatorcontrib>Razjoyan, Hadi</creatorcontrib><creatorcontrib>Mamarabadi, Mansoureh</creatorcontrib><creatorcontrib>Alimohamadi, Meysam</creatorcontrib><creatorcontrib>Tavangar, Seyed Mohamad</creatorcontrib><creatorcontrib>Malekzadeh, Reza</creatorcontrib><title>Liver histology and HBV DNA levels in chronically HBV infected patients with persistently normal alanine aminotransferase</title><title>Archives of Iranian medicine</title><addtitle>Arch Iran Med</addtitle><description>Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients.
There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed.
A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score > or = 5, 53 cases (40.2%) had grade > or = 4 and 40 cases (30.3%) had stage > or = 2. A baseline HBV DNA <2000 IU/mL was seen in 24 cases (48%) of those with total score > or = 5, 28 cases (53%) of those with grade > or = 4 and 9 cases (22.5%) with stage > or = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by > or = 2 scores and the HBV DNA of 18 cases (22.5%) increased by > or = 1 Log10 IU when compared to baseline values.
HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Analysis of Variance</subject><subject>Biopsy, Needle</subject><subject>Cohort Studies</subject><subject>DNA, Viral - analysis</subject><subject>Follow-Up Studies</subject><subject>Hepatitis B e Antigens - blood</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - enzymology</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Linear Models</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Multivariate Analysis</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><issn>1029-2977</issn><issn>1735-3947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo1kEtPwzAQhC0EoqXwF5DFPdLGjwQfS3kUqYILcI2cZENdOU6w3aL8eywopx3tfprR7AmZ5yWXGVeiPE0amMqYKssZuQhhByC4zPk5mbGkOGN8TqaNOaCnWxPiYIfPiWrX0vXdB71_WVKLB7SBGkebrR-cabS10-_VuA6biC0ddTToYqDfJm7piD4kp7RInBt8ry3VVjvjkOreuCF67UKHXge8JGedtgGvjnNB3h8f3lbrbPP69LxabrKRgYyZTFUklFIXbSOlEKoQSnFoOKhWd10NSud52RS3IFrI81ooKQsFAJLVOSLnC3Lz5zv64WuPIVa7Ye9diqwkCOCqKGWCro_Qvu6xrUZveu2n6v9R_Ad_r2VO</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Montazeri, Ghodrate</creator><creator>Rahban, Maryam</creator><creator>Mohamadnejad, Mehdi</creator><creator>Zamani, Farhad</creator><creator>Hooshyar, Afshin</creator><creator>Fazlolahi, Atoosa</creator><creator>Abedian, Shifteh</creator><creator>Ghoujeghi, Farhad</creator><creator>Estakhri, Arezoo</creator><creator>Montazeri, Farhad</creator><creator>Razjoyan, Hadi</creator><creator>Mamarabadi, Mansoureh</creator><creator>Alimohamadi, Meysam</creator><creator>Tavangar, Seyed Mohamad</creator><creator>Malekzadeh, Reza</creator><general>Academy of Medical Sciences of I.R. 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We aimed to investigate the histological activity and HBV DNA levels in these patients.
There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed.
A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total score > or = 5, 53 cases (40.2%) had grade > or = 4 and 40 cases (30.3%) had stage > or = 2. A baseline HBV DNA <2000 IU/mL was seen in 24 cases (48%) of those with total score > or = 5, 28 cases (53%) of those with grade > or = 4 and 9 cases (22.5%) with stage > or = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed by > or = 2 scores and the HBV DNA of 18 cases (22.5%) increased by > or = 1 Log10 IU when compared to baseline values.
HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL.</abstract><cop>Iran</cop><pub>Academy of Medical Sciences of I.R. Iran</pub><pmid>20433223</pmid></addata></record> |
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| subjects | Adult Age Factors Aged Alanine Transaminase - blood Analysis of Variance Biopsy, Needle Cohort Studies DNA, Viral - analysis Follow-Up Studies Hepatitis B e Antigens - blood Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - enzymology Hepatitis B, Chronic - pathology Humans Immunohistochemistry Linear Models Liver Function Tests Male Middle Aged Monitoring, Physiologic - methods Multivariate Analysis Reference Values Retrospective Studies Risk Assessment ROC Curve Sensitivity and Specificity Severity of Illness Index Time Factors |
| title | Liver histology and HBV DNA levels in chronically HBV infected patients with persistently normal alanine aminotransferase |
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