Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation

Cell adhesion molecules are key players in transsynaptic communication, precisely coordinating presynaptic differentiation with postsynaptic specialization. At glutamatergic synapses, their retrograde signaling has been proposed to control presynaptic vesicle clustering at active zones. However, how...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-06, Vol.107 (24), p.11116-11121
Hauptverfasser:	Stan, A., Pielarski, K. N., Brigadski, T., Wittenmayer, N., Fedorchenko, O., Gohla, A., Lessmann, V., Dresbach, T., Gottmann, K., Südhof, Thomas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type II - genetics Activin Receptors, Type II - metabolism Adhesion Animals Base Sequence Biological Sciences CA3 Region, Hippocampal - physiology Cadherins Cadherins - deficiency Cadherins - genetics Cadherins - physiology Catenins Cell adhesion & migration Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - physiology Cells, Cultured Dendrites Embryonic Stem Cells - physiology Fluorescence Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism In Vitro Techniques Membranes Mice Mice, Knockout Mice, Transgenic Miniature Postsynaptic Potentials Molecules Neurons Neurons - physiology Neuroscience Neurosciences Proteins Pyramidal Cells - physiology Rats Rats, Wistar Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism RNA Interference RNA, Small Interfering - genetics Synapses Synaptic Vesicles - physiology Threshing
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