Formation and Attachment of the Deoxysugar Moiety and Assembly of the Gene Cluster for Caprazamycin Biosynthesis

Caprazamycins are antimycobacterials produced by Streptomyces sp. MK730-62F2. Previously, cosmid cpzLK09 was shown to direct the biosynthesis of caprazamycin aglycones, but not of intact caprazamycins. Sequence analysis of cpzLK09 identified 23 genes involved in the formation of the caprazamycin agl...

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Veröffentlicht in:	Applied and Environmental Microbiology 2010-06, Vol.76 (12), p.4008-4018
Hauptverfasser:	Kaysser, Leonard, Wemakor, Emmanuel, Siebenberg, Stefanie, Salas, Jose A, Sohng, Jae Kyung, Kammerer, Bernd, Gust, Bertolt
Format:	Artikel
Sprache:	eng
Schlagworte:	Aglycones Antibiotics Antitubercular Agents - metabolism Azepines Bacteriology Biological and medical sciences Biosynthesis Biosynthetic Pathways - genetics Deoxy Sugars - metabolism DNA, Bacterial - chemistry DNA, Bacterial - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Knockout Techniques Genes, Bacterial Genetic Engineering Genetics and Molecular Biology Gram-positive bacteria Microbiology Molecular Sequence Data Multigene Family Mutagenesis, Insertional Sequence Analysis, DNA Streptomyces Streptomyces coelicolor - genetics Streptomyces coelicolor - metabolism Sugar Uridine - analogs & derivatives Uridine - biosynthesis
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