Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons

Many have hypothesized that cell death in Parkinson's disease is via apoptosis and, specifically, by the mitochondrial-mediated apoptotic pathway. We tested this hypothesis using a mouse dopaminergic cell line of mesencephalic origin, MN9D, challenged with the Parkinsonism-causing neurotoxin MP...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2005-01, Vol.62 (2), p.227-238
Hauptverfasser:	Chee, J L Y, Guan, X L, Lee, J Y, Dong, B, Leong, S M, Ong, E H, Liou, A K F, Lim, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - toxicity Animals Apoptosis Apoptosis Inducing Factor Caspase 2 Caspase 3 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspases - metabolism Cell death Cell Line Cytochromes c - biosynthesis Dopamine - metabolism Enzyme Activation Enzymes Flavoproteins - metabolism Membrane Proteins - metabolism Mice Mitochondria - metabolism Mortality Neurons Neurons - cytology Neurons - drug effects Neurons - enzymology Neurotoxins Neurotransmitters Parkinson's disease
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