Stereo‐ and Chemoselective Enrichment of sp3 Character in Post‐Ugi Morpholines

We conducted a systematic study on synthesis and modification of morpholine core using Ugi adducts derived from propiolic acid and glycolaldehyde dimer. The assembly step involved triphenylphosphine‐promoted 6‐exo‐dig umpolung oxa‐Michael cyclization of Ugi‐derived hydroxypropargylamides yielding 2‐...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of organic chemistry 2025-01, Vol.28 (4), p.n/a
Hauptverfasser:	Hasan, Muhammad, Nuroldayeva, Gulzat A., Begenov, Azamat, Peshkov, Anatoly A., Martynova, Sofia D., Amire, Niyaz, Bekbolatova, Ainara, Makhmet, Azat M., Yu, Jiafeng, Zaman, Manzoor, Gong, Jing, Lim, Chang‐Keun, Belyaev, Andrey, Pereshivko, Olga P., Wang, Shunyi, Peshkov, Vsevolod A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Aluminum hydrides chemoselectivity diastereoselectivity Lithium aluminum hydrides Metal hydrides morpholines post-Ugi transformations Scaffolds sp3-enriched heterocycles Stereoselectivity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!