Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti...
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| Veröffentlicht in: | Antioxidants 2024-12, Vol.14 (1), p.4 |
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| creator | Matamoros, José A Rubio-Casado, Sara Fernández-Albarral, José A Martínez-López, Miguel A Salobrar-García, Elena Marco, Eva M Paleo-García, Victor de Hoz, Rosa López-Cuenca, Inés Elvira-Hurtado, Lorena Sánchez-Puebla, Lidia Ramírez, José M Salazar, Juan J López-Gallardo, Meritxell Ramírez, Ana I |
| description | Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (
= 6), citicoline + CoQ10 group (
= 6), laser-vehicle group (
= 6), and laser-citicoline + CoQ10 group (
= 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser-citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT. |
| doi_str_mv | 10.3390/antiox14010004 |
| format | Article |
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= 6), citicoline + CoQ10 group (
= 6), laser-vehicle group (
= 6), and laser-citicoline + CoQ10 group (
= 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser-citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT.</description><identifier>ISSN: 2076-3921</identifier><identifier>EISSN: 2076-3921</identifier><identifier>DOI: 10.3390/antiox14010004</identifier><identifier>PMID: 39857338</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anesthesia ; Anti-inflammatory agents ; Brn-3 protein ; Citicoline ; Coenzyme Q10 ; Death ; Drinking water ; experimental glaucoma ; Eye diseases ; ganglion cells ; Glaucoma ; Hypertension ; Laboratory animals ; Lasers ; Neurodegeneration ; Neurodegenerative diseases ; Neuroprotection ; Oral administration ; Oxidative stress ; retina ; Retinal ganglion cells ; Risk factors ; Superior colliculus ; Visual cortex ; visual pathway ; Visual pathways</subject><ispartof>Antioxidants, 2024-12, Vol.14 (1), p.4</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2451-c1a74213c2acc27f772d3d15750cb6f85d626a57ba452fc828f18cbf71ce48d13</cites><orcidid>0000-0002-2020-2721 ; 0000-0002-2457-475X ; 0000-0003-0300-2602 ; 0000-0003-0607-5225 ; 0000-0001-5939-5551 ; 0000-0001-5480-5902 ; 0000-0001-7481-2536 ; 0000-0003-0511-515X ; 0000-0002-5145-5094 ; 0000-0002-2656-4723 ; 0000-0002-1581-087X ; 0000-0002-4430-8782 ; 0000-0003-0399-7996</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761561/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761561/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39857338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matamoros, José A</creatorcontrib><creatorcontrib>Rubio-Casado, Sara</creatorcontrib><creatorcontrib>Fernández-Albarral, José A</creatorcontrib><creatorcontrib>Martínez-López, Miguel A</creatorcontrib><creatorcontrib>Salobrar-García, Elena</creatorcontrib><creatorcontrib>Marco, Eva M</creatorcontrib><creatorcontrib>Paleo-García, Victor</creatorcontrib><creatorcontrib>de Hoz, Rosa</creatorcontrib><creatorcontrib>López-Cuenca, Inés</creatorcontrib><creatorcontrib>Elvira-Hurtado, Lorena</creatorcontrib><creatorcontrib>Sánchez-Puebla, Lidia</creatorcontrib><creatorcontrib>Ramírez, José M</creatorcontrib><creatorcontrib>Salazar, Juan J</creatorcontrib><creatorcontrib>López-Gallardo, Meritxell</creatorcontrib><creatorcontrib>Ramírez, Ana I</creatorcontrib><title>Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension</title><title>Antioxidants</title><addtitle>Antioxidants (Basel)</addtitle><description>Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (
= 6), citicoline + CoQ10 group (
= 6), laser-vehicle group (
= 6), and laser-citicoline + CoQ10 group (
= 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser-citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT.</description><subject>Anesthesia</subject><subject>Anti-inflammatory agents</subject><subject>Brn-3 protein</subject><subject>Citicoline</subject><subject>Coenzyme Q10</subject><subject>Death</subject><subject>Drinking water</subject><subject>experimental glaucoma</subject><subject>Eye diseases</subject><subject>ganglion cells</subject><subject>Glaucoma</subject><subject>Hypertension</subject><subject>Laboratory animals</subject><subject>Lasers</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Neuroprotection</subject><subject>Oral administration</subject><subject>Oxidative stress</subject><subject>retina</subject><subject>Retinal ganglion cells</subject><subject>Risk factors</subject><subject>Superior colliculus</subject><subject>Visual cortex</subject><subject>visual pathway</subject><subject>Visual pathways</subject><issn>2076-3921</issn><issn>2076-3921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1v1DAQhiMEolXplSOKxIXLFo8_YueE0KrQSoUKCc6WY49br7L2YicV_fc43VJ1udijmWfe-dA0zVsgZ4z15KOJU0h_gBMghPAXzTElsluxnsLLZ_ZRc1rKphKkB6ZI_7o5Yr0SkjF13ITvOOe0y2lCO4U7bM-9r1abfDvdYrtO2yFEU8vExbUOU7BpDBFbE12N_gDShtia9luaC9bX4biA13YeTW4v7neYJ4yl5r9pXnkzFjx9_E-aX1_Of64vVlfXXy_Xn69WlnIBKwtGcgrMUmMtlV5K6pgDIQWxQ-eVcB3tjJCD4YJ6q6jyoOzgJVjkygE7aS73ui6Zjd7lsDX5XicT9IMj5Rttch1jRI2eM8U7LofOcq9UlbK0c9D3nDqBtGp92mvt5mGLzmKcshkPRA8jMdzqm3SnAWQHolu6-fCokNPvGcukt6FYHEcTsa5MMxC9IoQyUdH3_6GbNOdYd_VAUUFpv1Bne8rmVEpG_9QNEL1chT68iprw7vkMT_i_G2B_AZqssvQ</recordid><startdate>20241224</startdate><enddate>20241224</enddate><creator>Matamoros, José A</creator><creator>Rubio-Casado, Sara</creator><creator>Fernández-Albarral, José A</creator><creator>Martínez-López, Miguel A</creator><creator>Salobrar-García, Elena</creator><creator>Marco, Eva M</creator><creator>Paleo-García, Victor</creator><creator>de Hoz, Rosa</creator><creator>López-Cuenca, Inés</creator><creator>Elvira-Hurtado, Lorena</creator><creator>Sánchez-Puebla, Lidia</creator><creator>Ramírez, José M</creator><creator>Salazar, Juan J</creator><creator>López-Gallardo, Meritxell</creator><creator>Ramírez, Ana I</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2020-2721</orcidid><orcidid>https://orcid.org/0000-0002-2457-475X</orcidid><orcidid>https://orcid.org/0000-0003-0300-2602</orcidid><orcidid>https://orcid.org/0000-0003-0607-5225</orcidid><orcidid>https://orcid.org/0000-0001-5939-5551</orcidid><orcidid>https://orcid.org/0000-0001-5480-5902</orcidid><orcidid>https://orcid.org/0000-0001-7481-2536</orcidid><orcidid>https://orcid.org/0000-0003-0511-515X</orcidid><orcidid>https://orcid.org/0000-0002-5145-5094</orcidid><orcidid>https://orcid.org/0000-0002-2656-4723</orcidid><orcidid>https://orcid.org/0000-0002-1581-087X</orcidid><orcidid>https://orcid.org/0000-0002-4430-8782</orcidid><orcidid>https://orcid.org/0000-0003-0399-7996</orcidid></search><sort><creationdate>20241224</creationdate><title>Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension</title><author>Matamoros, José A ; Rubio-Casado, Sara ; Fernández-Albarral, José A ; Martínez-López, Miguel A ; Salobrar-García, Elena ; Marco, Eva M ; Paleo-García, Victor ; de Hoz, Rosa ; López-Cuenca, Inés ; Elvira-Hurtado, Lorena ; Sánchez-Puebla, Lidia ; Ramírez, José M ; Salazar, Juan J ; López-Gallardo, Meritxell ; Ramírez, Ana I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2451-c1a74213c2acc27f772d3d15750cb6f85d626a57ba452fc828f18cbf71ce48d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anesthesia</topic><topic>Anti-inflammatory agents</topic><topic>Brn-3 protein</topic><topic>Citicoline</topic><topic>Coenzyme Q10</topic><topic>Death</topic><topic>Drinking water</topic><topic>experimental glaucoma</topic><topic>Eye diseases</topic><topic>ganglion cells</topic><topic>Glaucoma</topic><topic>Hypertension</topic><topic>Laboratory animals</topic><topic>Lasers</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Neuroprotection</topic><topic>Oral administration</topic><topic>Oxidative stress</topic><topic>retina</topic><topic>Retinal ganglion cells</topic><topic>Risk factors</topic><topic>Superior colliculus</topic><topic>Visual cortex</topic><topic>visual pathway</topic><topic>Visual pathways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matamoros, José A</creatorcontrib><creatorcontrib>Rubio-Casado, Sara</creatorcontrib><creatorcontrib>Fernández-Albarral, José A</creatorcontrib><creatorcontrib>Martínez-López, Miguel A</creatorcontrib><creatorcontrib>Salobrar-García, Elena</creatorcontrib><creatorcontrib>Marco, Eva M</creatorcontrib><creatorcontrib>Paleo-García, Victor</creatorcontrib><creatorcontrib>de Hoz, Rosa</creatorcontrib><creatorcontrib>López-Cuenca, Inés</creatorcontrib><creatorcontrib>Elvira-Hurtado, Lorena</creatorcontrib><creatorcontrib>Sánchez-Puebla, Lidia</creatorcontrib><creatorcontrib>Ramírez, José M</creatorcontrib><creatorcontrib>Salazar, Juan J</creatorcontrib><creatorcontrib>López-Gallardo, Meritxell</creatorcontrib><creatorcontrib>Ramírez, Ana I</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antioxidants</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matamoros, José A</au><au>Rubio-Casado, Sara</au><au>Fernández-Albarral, José A</au><au>Martínez-López, Miguel A</au><au>Salobrar-García, Elena</au><au>Marco, Eva M</au><au>Paleo-García, Victor</au><au>de Hoz, Rosa</au><au>López-Cuenca, Inés</au><au>Elvira-Hurtado, Lorena</au><au>Sánchez-Puebla, Lidia</au><au>Ramírez, José M</au><au>Salazar, Juan J</au><au>López-Gallardo, Meritxell</au><au>Ramírez, Ana I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension</atitle><jtitle>Antioxidants</jtitle><addtitle>Antioxidants (Basel)</addtitle><date>2024-12-24</date><risdate>2024</risdate><volume>14</volume><issue>1</issue><spage>4</spage><pages>4-</pages><issn>2076-3921</issn><eissn>2076-3921</eissn><abstract>Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (
= 6), citicoline + CoQ10 group (
= 6), laser-vehicle group (
= 6), and laser-citicoline + CoQ10 group (
= 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser-citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39857338</pmid><doi>10.3390/antiox14010004</doi><orcidid>https://orcid.org/0000-0002-2020-2721</orcidid><orcidid>https://orcid.org/0000-0002-2457-475X</orcidid><orcidid>https://orcid.org/0000-0003-0300-2602</orcidid><orcidid>https://orcid.org/0000-0003-0607-5225</orcidid><orcidid>https://orcid.org/0000-0001-5939-5551</orcidid><orcidid>https://orcid.org/0000-0001-5480-5902</orcidid><orcidid>https://orcid.org/0000-0001-7481-2536</orcidid><orcidid>https://orcid.org/0000-0003-0511-515X</orcidid><orcidid>https://orcid.org/0000-0002-5145-5094</orcidid><orcidid>https://orcid.org/0000-0002-2656-4723</orcidid><orcidid>https://orcid.org/0000-0002-1581-087X</orcidid><orcidid>https://orcid.org/0000-0002-4430-8782</orcidid><orcidid>https://orcid.org/0000-0003-0399-7996</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Antioxidants, 2024-12, Vol.14 (1), p.4 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Anesthesia Anti-inflammatory agents Brn-3 protein Citicoline Coenzyme Q10 Death Drinking water experimental glaucoma Eye diseases ganglion cells Glaucoma Hypertension Laboratory animals Lasers Neurodegeneration Neurodegenerative diseases Neuroprotection Oral administration Oxidative stress retina Retinal ganglion cells Risk factors Superior colliculus Visual cortex visual pathway Visual pathways |
| title | Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
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