Assessment of Erythrocytes Methotrexate Polyglutamate Three Levels in Psoriatic Patients Treated with Methotrexate Monotherapy and Their Association with Disease Response

Methotrexate is used to manage moderate to severe psoriasis and psoriatic arthritis. Methotrexate acts by inhibiting the enzymes involved in nucleotide synthesis. Methotrexate polyglutamates (MTXPGs) have a higher potency to inhibit Dihydrofolate reductase (DHFR), 5-aminoimidazole-4-carboxamide ribo...

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Veröffentlicht in:	Indian journal of clinical biochemistry 2025, Vol.40 (1), p.89-96
Hauptverfasser:	Goud, Veera Krishna, Goud, Alladi Charanraj, Ramassamy, Sivaranjini, Jayanthi, M., Medha, R., Chandrashekar, Laxmisha
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Chemistry/Food Science Dihydrofolate reductase Enzyme inhibitors Enzymes Erythrocytes Inflammatory diseases Life Sciences Liquid chromatography Methotrexate Microbiology Original Research Article Pathology Psoriasis Psoriatic arthritis Side effects Spectrophotometry Thymidylate synthase Transformylase
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