Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms
A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA...
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| Veröffentlicht in: | Journal of contemporary physics 2024-09, Vol.59 (3), p.347-352 |
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| container_end_page | 352 |
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| container_start_page | 347 |
| container_title | Journal of contemporary physics |
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| creator | Ananyan, G. V. Karapetyan, N. H. Dalyan, Y. B. Ghazaryan, R. S. Haroutiunian, S. G. |
| description | A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (
H
-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure. |
| doi_str_mv | 10.1134/S106833722470035X |
| format | Article |
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H
-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.</description><identifier>ISSN: 1068-3372</identifier><identifier>EISSN: 1934-9378</identifier><identifier>DOI: 10.1134/S106833722470035X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Absorption spectra ; Adsorption ; Binding ; Comparative studies ; Isotherms ; Parameters ; Particle and Nuclear Physics ; Physics ; Physics and Astronomy ; Porphyrins</subject><ispartof>Journal of contemporary physics, 2024-09, Vol.59 (3), p.347-352</ispartof><rights>Pleiades Publishing, Ltd. 2024 ISSN 1068-3372, Journal of Contemporary Physics (Armenian Academy of Sciences), 2024, Vol. 59, No. 3, pp. 347–352. © Pleiades Publishing, Ltd., 2024.Russian Text © The Author(s), 2024, published in Izvestiya Natsional'noi Akademii Nauk Armenii, Fizika, 2024, Vol. 59, No. 3, pp. 398–405.</rights><rights>Copyright Springer Nature B.V. 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-93c638493b740114d4f79abe85e83b5cda4324e793c0c7434a61fcfa6e3115ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S106833722470035X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S106833722470035X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Ananyan, G. V.</creatorcontrib><creatorcontrib>Karapetyan, N. H.</creatorcontrib><creatorcontrib>Dalyan, Y. B.</creatorcontrib><creatorcontrib>Ghazaryan, R. S.</creatorcontrib><creatorcontrib>Haroutiunian, S. G.</creatorcontrib><title>Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms</title><title>Journal of contemporary physics</title><addtitle>J. Contemp. Phys</addtitle><description>A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (
H
-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.</description><subject>Absorption spectra</subject><subject>Adsorption</subject><subject>Binding</subject><subject>Comparative studies</subject><subject>Isotherms</subject><subject>Parameters</subject><subject>Particle and Nuclear Physics</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>Porphyrins</subject><issn>1068-3372</issn><issn>1934-9378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLw0AQhRdRsFZ_gLcFz9GdzG6yOcZotVA0YAsehLBNNm1Ku1t300P_vVsqehBPM8P73szwCLkGdguA_O4NWCIR0zjmKWMo3k_IADLkUYapPA19kKODfk4uvF8xJkRQB-TjvjNNZxa0VE5tdK-dp7alxW6ar9flvuRUmYYW9mcsrdsu964znvaWPrzkdOYP_rzxQek7a-jY236p3cZfkrNWrb2--q5DMhs9TovnaPL6NC7ySVRDJvvwYp2g5BnOU84AeMPbNFNzLYWWOBd1ozjGXKeBY3XKkasE2rpViUYAoTUOyc1x79bZz532fbWyO2fCyQpBJEzKmEGg4EjVznrvdFttXbdRbl8Bqw4hVn9CDJ746PGBNQvtfjf_b_oCb8dyVw</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Ananyan, G. V.</creator><creator>Karapetyan, N. H.</creator><creator>Dalyan, Y. B.</creator><creator>Ghazaryan, R. S.</creator><creator>Haroutiunian, S. G.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20240901</creationdate><title>Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms</title><author>Ananyan, G. V. ; Karapetyan, N. H. ; Dalyan, Y. B. ; Ghazaryan, R. S. ; Haroutiunian, S. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-93c638493b740114d4f79abe85e83b5cda4324e793c0c7434a61fcfa6e3115ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Absorption spectra</topic><topic>Adsorption</topic><topic>Binding</topic><topic>Comparative studies</topic><topic>Isotherms</topic><topic>Parameters</topic><topic>Particle and Nuclear Physics</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>Porphyrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ananyan, G. V.</creatorcontrib><creatorcontrib>Karapetyan, N. H.</creatorcontrib><creatorcontrib>Dalyan, Y. B.</creatorcontrib><creatorcontrib>Ghazaryan, R. S.</creatorcontrib><creatorcontrib>Haroutiunian, S. G.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of contemporary physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ananyan, G. V.</au><au>Karapetyan, N. H.</au><au>Dalyan, Y. B.</au><au>Ghazaryan, R. S.</au><au>Haroutiunian, S. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms</atitle><jtitle>Journal of contemporary physics</jtitle><stitle>J. Contemp. Phys</stitle><date>2024-09-01</date><risdate>2024</risdate><volume>59</volume><issue>3</issue><spage>347</spage><epage>352</epage><pages>347-352</pages><issn>1068-3372</issn><eissn>1934-9378</eissn><abstract>A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (
H
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| subjects | Absorption spectra Adsorption Binding Comparative studies Isotherms Parameters Particle and Nuclear Physics Physics Physics and Astronomy Porphyrins |
| title | Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms |
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