Investigation of the effect of yarrow (Achillea millefolium) on Ehrlich ascites tumor
One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours a...
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| Veröffentlicht in: | Postȩpy higieny i medycyny doświadczalnej 2022-01, Vol.76 (1), p.431-443 |
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| container_title | Postȩpy higieny i medycyny doświadczalnej |
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| creator | Nisari, Mustafa İnanç, Neriman Tokpınar, Adem Al, Özge Uçar, Sümeyye Taştan, Mustafa Ateş, Şükrü Yılmaz, Seher |
| description | One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a shaking water bath. In the study, EAT cells were divided into control, DMSO group 5-FU, 50, 100, 200, 400 and 800 μg/ml YP groups.At the end of the hour, it was observed that total apoptosis increased significantly in Y groups (especially 50 μg/ml) compared to the control group (p |
| doi_str_mv | 10.2478/ahem-2022-0028 |
| format | Article |
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The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a shaking water bath. In the study, EAT cells were divided into control, DMSO group 5-FU, 50, 100, 200, 400 and 800 μg/ml YP groups.At the end of the hour, it was observed that total apoptosis increased significantly in Y groups (especially 50 μg/ml) compared to the control group (p<0.05). It was observed that Y slowed the division of EAT cells (especially 800 μg/ml) by stopping the cell cycle at the G0/G1 stage. It was concluded that Y (especially at high doses) triggered apoptosis by significantly increasing the percentage of total depolarized cells (p<0.001) in all three time periods.The results obtained showed that Y extract may have an antitumoral effect on EAT cells. 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| source | Walter De Gruyter: Open Access Journals; EZB Electronic Journals Library |
| subjects | animal Antioxidants apoptosis Ascites Cancer cell Cell cycle EAT Flowers & plants Herbal medicine yarrow |
| title | Investigation of the effect of yarrow (Achillea millefolium) on Ehrlich ascites tumor |
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