The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats
: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats. : The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic...
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Veröffentlicht in: | Acta Medica Marisiensis 2015-12, Vol.61 (4), p.282-286 |
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creator | Bianca-Liana, Grigorescu Ştefania, Fodor Raluca Alina, Scridon Marcel, Perian Iudita, Badea Adrian Dan, Cioc Simion, Cotoi Ovidiu Sanda-Maria, Copotoiu Leonard, Azamfirei |
description | : The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats.
: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).
: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.
: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats. |
doi_str_mv | 10.1515/amma-2015-0087 |
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: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).
: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.
: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats.</description><identifier>ISSN: 2247-6113</identifier><identifier>ISSN: 2068-3324</identifier><identifier>EISSN: 2247-6113</identifier><identifier>DOI: 10.1515/amma-2015-0087</identifier><language>eng</language><publisher>Tirgu-Mures: De Gruyter Open</publisher><subject>contractility ; Diabetes ; Ischemia ; ischemic preconditioning ; Kinases ; reperfusion injury ; skeletal muscle</subject><ispartof>Acta Medica Marisiensis, 2015-12, Vol.61 (4), p.282-286</ispartof><rights>2015. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Bianca-Liana, Grigorescu</creatorcontrib><creatorcontrib>Ştefania, Fodor Raluca</creatorcontrib><creatorcontrib>Alina, Scridon</creatorcontrib><creatorcontrib>Marcel, Perian</creatorcontrib><creatorcontrib>Iudita, Badea</creatorcontrib><creatorcontrib>Adrian Dan, Cioc</creatorcontrib><creatorcontrib>Simion, Cotoi Ovidiu</creatorcontrib><creatorcontrib>Sanda-Maria, Copotoiu</creatorcontrib><creatorcontrib>Leonard, Azamfirei</creatorcontrib><title>The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats</title><title>Acta Medica Marisiensis</title><description>: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats.
: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).
: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.
: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats.</description><subject>contractility</subject><subject>Diabetes</subject><subject>Ischemia</subject><subject>ischemic preconditioning</subject><subject>Kinases</subject><subject>reperfusion injury</subject><subject>skeletal muscle</subject><issn>2247-6113</issn><issn>2068-3324</issn><issn>2247-6113</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUE1LAzEUDKJgqb16XvC8NS_ZbLbgpdSvQkEp9eIlZDcvdkt3U5NdpP_eLBX04OnNG2bm8YaQa6BTECBuddPolFEQKaWFPCMjxjKZ5gD8_A--JJMQdpRSkLwAmo_I-2aLyTwEDKHBtkucTdZ4QG_7ULs2WbZ2P0R3zh_jsuvjqCMdqi02dZW8eqxca-ouitEk97UusYv8WnfhilxYvQ84-Zlj8vb4sFk8p6uXp-VivkoryClLM8ZLLqTQSEVpZlJqLo3OMyOKkprIMco1Fhy0RGHsTFgoLZqS68poaykfk5tT7sG7zx5Dp3au9208qTgIIZgsxCyqpidV5V0IHq06-LrR_qiAqqFCNfyphgrVUGE03J0MX3rfoTf44ftjBL_p_xtzyFjB-DclSnlL</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Bianca-Liana, Grigorescu</creator><creator>Ştefania, Fodor Raluca</creator><creator>Alina, Scridon</creator><creator>Marcel, Perian</creator><creator>Iudita, Badea</creator><creator>Adrian Dan, Cioc</creator><creator>Simion, Cotoi Ovidiu</creator><creator>Sanda-Maria, Copotoiu</creator><creator>Leonard, Azamfirei</creator><general>De Gruyter Open</general><general>De Gruyter Poland</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20151201</creationdate><title>The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats</title><author>Bianca-Liana, Grigorescu ; Ştefania, Fodor Raluca ; Alina, Scridon ; Marcel, Perian ; Iudita, Badea ; Adrian Dan, Cioc ; Simion, Cotoi Ovidiu ; Sanda-Maria, Copotoiu ; Leonard, Azamfirei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1602-423b3575ae05bd977a37da64d58b0d05b203ae831a7e5df95f1bfedb3acdaff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>contractility</topic><topic>Diabetes</topic><topic>Ischemia</topic><topic>ischemic preconditioning</topic><topic>Kinases</topic><topic>reperfusion injury</topic><topic>skeletal muscle</topic><toplevel>online_resources</toplevel><creatorcontrib>Bianca-Liana, Grigorescu</creatorcontrib><creatorcontrib>Ştefania, Fodor Raluca</creatorcontrib><creatorcontrib>Alina, Scridon</creatorcontrib><creatorcontrib>Marcel, Perian</creatorcontrib><creatorcontrib>Iudita, Badea</creatorcontrib><creatorcontrib>Adrian Dan, Cioc</creatorcontrib><creatorcontrib>Simion, Cotoi Ovidiu</creatorcontrib><creatorcontrib>Sanda-Maria, Copotoiu</creatorcontrib><creatorcontrib>Leonard, Azamfirei</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Acta Medica Marisiensis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bianca-Liana, Grigorescu</au><au>Ştefania, Fodor Raluca</au><au>Alina, Scridon</au><au>Marcel, Perian</au><au>Iudita, Badea</au><au>Adrian Dan, Cioc</au><au>Simion, Cotoi Ovidiu</au><au>Sanda-Maria, Copotoiu</au><au>Leonard, Azamfirei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats</atitle><jtitle>Acta Medica Marisiensis</jtitle><date>2015-12-01</date><risdate>2015</risdate><volume>61</volume><issue>4</issue><spage>282</spage><epage>286</epage><pages>282-286</pages><issn>2247-6113</issn><issn>2068-3324</issn><eissn>2247-6113</eissn><abstract>: The assessment of systemic reperfusion injury and the contractile force of the peripheral muscles post-acute ischemia of the hind limbs in healthy versus diabetic ischemic preconditioned rats.
: The study included 16 Wistar rats divided into two groups: the control group and the diabetic ischemic preconditioned group. Acute ischemia was induced, followed by reperfusion. The assessment of reperfusion injury used biochemical, histopathological and functional determinations (peak tetanic tension-PTT, specific tension-ST).
: Ischemia-reperfusion injury was more severe in control group regarding creatine-kinase (CK) (CK1=470.13 IU/L versus CK2=230.88 IU/L, p=0.0001) and myoglobin (390.25 ng/mL versus 47.99 ng/mL, p=0.025). Cytolysis enzymes were significantly increased in diabetic preconditioned rats (Alanine aminotransferase ALAT1=46 IU/L, ALAT2=167.8 IU/L, p=0.02; Aspartate aminotransferase ASAT1=106 IU/L, ASAT2=237.5 IU/L, p=0.016). Functional assessment (PTT and ST) highlighted roughly equal values. A paradoxical response occurred in diabetic rats (the contractile force increased during the period of the stimulation). Histopathological findings showed that rhabdomyolysis was more severe in the control group, while inflammatory systemic response due to reperfusion injury was less expressed in diabetic ischemic preconditioned rats.
: Ischemic preconditioning reduces the severity of reperfusion injury and allows the preservation of contractile muscle function in diabetic rats.</abstract><cop>Tirgu-Mures</cop><pub>De Gruyter Open</pub><doi>10.1515/amma-2015-0087</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | contractility Diabetes Ischemia ischemic preconditioning Kinases reperfusion injury skeletal muscle |
title | The Assessment of Reperfusion Inflammatory Injury in Ischemic Preconditioned Diabetic Rats |
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