Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics
Background Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GER...
Gespeichert in:
| Veröffentlicht in: | Asian biomedicine 2017-01, Vol.9 (2), p.139-145 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 145 |
|---|---|
| container_issue | 2 |
| container_start_page | 139 |
| container_title | Asian biomedicine |
| container_volume | 9 |
| creator | Jaimchariyatam, Nattapong Haprasert, Phurin Gonchanvit, Sutep Wongtim, Somkiat |
| description | Background Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand. Objectives To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores. Methods This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up. Results Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05).Conclusion High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD. |
| doi_str_mv | 10.5372/1905-7415.0902.379 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3153889090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153889090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-a4c1f92a54f054522c18a4d1f9dbb9a85f8b2b91f5e8ff3af81b938a2ba6cf043</originalsourceid><addsrcrecordid>eNp1kEtLAzEUhYMoWKt_wFXA9dQ8Jp1kJVJ8QaEbBXfhzkwybZlpxmSi1l9vhgq6cXUvl3PO5XwIXVIyE7xg11QRkRU5FTOiCJvxQh2hCZWFyKQQr8d_9lN0FsKWkDmjVE5QsyqD8e8wbNwOWhyGWO-xs9h1pvfw5VqDrfO4gTB4Z4Lr19CYJPTGtvETux3uY9slr99jG3fVmIM3Owx1bAecXOsuZVfhHJ1YaIO5-JlT9HJ_97x4zJarh6fF7TKrOJsPGeQVtYqByC0RuWCsohLyOt3qslQghZUlKxW1wkhrOVhJS8UlsBLmlSU5n6KrQ27v3Vs0YdBbF32qFjSngkupEqCkYgdV5V0IqYvu_aZLHTQlegSqR6B6BKpHoDoBTaabg-kD2sH42jQ-7tPy--F_s2KUK_4NLkl_tw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3153889090</pqid></control><display><type>article</type><title>Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics</title><source>De Gruyter Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Jaimchariyatam, Nattapong ; Haprasert, Phurin ; Gonchanvit, Sutep ; Wongtim, Somkiat</creator><creatorcontrib>Jaimchariyatam, Nattapong ; Haprasert, Phurin ; Gonchanvit, Sutep ; Wongtim, Somkiat</creatorcontrib><description>Background Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand. Objectives To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores. Methods This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up. Results Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05).Conclusion High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.</description><identifier>ISSN: 1875-855X</identifier><identifier>ISSN: 1905-7415</identifier><identifier>EISSN: 1875-855X</identifier><identifier>DOI: 10.5372/1905-7415.0902.379</identifier><language>eng</language><publisher>Bangkok: De Gruyter Open</publisher><subject>Asthma ; Esophagus ; Females ; Gastroesophageal reflux ; GERD ; Hay fever ; Observational studies ; omeprazole ; pulmonary function test ; Rhinitis ; Steroids ; symptom assessment</subject><ispartof>Asian biomedicine, 2017-01, Vol.9 (2), p.139-145</ispartof><rights>2015. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-a4c1f92a54f054522c18a4d1f9dbb9a85f8b2b91f5e8ff3af81b938a2ba6cf043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.5372/1905-7415.0902.379/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.5372/1905-7415.0902.379/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,67129,68913</link.rule.ids></links><search><creatorcontrib>Jaimchariyatam, Nattapong</creatorcontrib><creatorcontrib>Haprasert, Phurin</creatorcontrib><creatorcontrib>Gonchanvit, Sutep</creatorcontrib><creatorcontrib>Wongtim, Somkiat</creatorcontrib><title>Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics</title><title>Asian biomedicine</title><description>Background Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand. Objectives To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores. Methods This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up. Results Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05).Conclusion High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.</description><subject>Asthma</subject><subject>Esophagus</subject><subject>Females</subject><subject>Gastroesophageal reflux</subject><subject>GERD</subject><subject>Hay fever</subject><subject>Observational studies</subject><subject>omeprazole</subject><subject>pulmonary function test</subject><subject>Rhinitis</subject><subject>Steroids</subject><subject>symptom assessment</subject><issn>1875-855X</issn><issn>1905-7415</issn><issn>1875-855X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kEtLAzEUhYMoWKt_wFXA9dQ8Jp1kJVJ8QaEbBXfhzkwybZlpxmSi1l9vhgq6cXUvl3PO5XwIXVIyE7xg11QRkRU5FTOiCJvxQh2hCZWFyKQQr8d_9lN0FsKWkDmjVE5QsyqD8e8wbNwOWhyGWO-xs9h1pvfw5VqDrfO4gTB4Z4Lr19CYJPTGtvETux3uY9slr99jG3fVmIM3Owx1bAecXOsuZVfhHJ1YaIO5-JlT9HJ_97x4zJarh6fF7TKrOJsPGeQVtYqByC0RuWCsohLyOt3qslQghZUlKxW1wkhrOVhJS8UlsBLmlSU5n6KrQ27v3Vs0YdBbF32qFjSngkupEqCkYgdV5V0IqYvu_aZLHTQlegSqR6B6BKpHoDoBTaabg-kD2sH42jQ-7tPy--F_s2KUK_4NLkl_tw</recordid><startdate>20170131</startdate><enddate>20170131</enddate><creator>Jaimchariyatam, Nattapong</creator><creator>Haprasert, Phurin</creator><creator>Gonchanvit, Sutep</creator><creator>Wongtim, Somkiat</creator><general>De Gruyter Open</general><general>De Gruyter Poland</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170131</creationdate><title>Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics</title><author>Jaimchariyatam, Nattapong ; Haprasert, Phurin ; Gonchanvit, Sutep ; Wongtim, Somkiat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-a4c1f92a54f054522c18a4d1f9dbb9a85f8b2b91f5e8ff3af81b938a2ba6cf043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Asthma</topic><topic>Esophagus</topic><topic>Females</topic><topic>Gastroesophageal reflux</topic><topic>GERD</topic><topic>Hay fever</topic><topic>Observational studies</topic><topic>omeprazole</topic><topic>pulmonary function test</topic><topic>Rhinitis</topic><topic>Steroids</topic><topic>symptom assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaimchariyatam, Nattapong</creatorcontrib><creatorcontrib>Haprasert, Phurin</creatorcontrib><creatorcontrib>Gonchanvit, Sutep</creatorcontrib><creatorcontrib>Wongtim, Somkiat</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Asian biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaimchariyatam, Nattapong</au><au>Haprasert, Phurin</au><au>Gonchanvit, Sutep</au><au>Wongtim, Somkiat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics</atitle><jtitle>Asian biomedicine</jtitle><date>2017-01-31</date><risdate>2017</risdate><volume>9</volume><issue>2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>1875-855X</issn><issn>1905-7415</issn><eissn>1875-855X</eissn><abstract>Background Asthma is a chronic inflammatory disease of airways. Gastroesophageal reflux disease (GERD) is known to be associated with worsening asthma. We hypothesized that treatment of GERD in asthmatics will improve asthma control and quality of life. We reviewed our experience of treatment of GERD in asthmatics in Thailand. Objectives To study the effects of omeprazole for treatment of GERD in patients with poorly controlled asthma on pulmonary function tests and asthma control test (ACT) scores. Methods This study was conducted at King Chulalongkorn Memorial Hospital between August 2009 and December 2010. Patients with partly controlled and uncontrolled asthma who were found to have GERD by 24 hour esophageal pH monitoring were administered omeprazole 40 mg per day for 8 weeks. Pulmonary function tests and ACT scores before and after treatment were compared at 4-weeks and 8-weeks follow up. Results Twenty four patients were included in this study. None of them had asthmatic attacks during the study. After 4 and 8 weeks of omeprazole treatment, the mean FEV1 (2.20 ± 0.64 L, 2.36 ± 0.58 L, respectively) and the mean ACT score (20.82 ± 3.30, 23.00 ± 1.69, respectively) were significantly higher than the pretreatment values (mean FEV1 1.99 ± 0.56 L and ACT score 16.36 ± 3.97) (P < 0.05).Conclusion High-dose omeprazole may improve pulmonary function and the level of asthma control in Thai patients with partly controlled or uncontrolled asthma and coexisting GERD.</abstract><cop>Bangkok</cop><pub>De Gruyter Open</pub><doi>10.5372/1905-7415.0902.379</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1875-855X |
| ispartof | Asian biomedicine, 2017-01, Vol.9 (2), p.139-145 |
| issn | 1875-855X 1905-7415 1875-855X |
| language | eng |
| recordid | cdi_proquest_journals_3153889090 |
| source | De Gruyter Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Asthma Esophagus Females Gastroesophageal reflux GERD Hay fever Observational studies omeprazole pulmonary function test Rhinitis Steroids symptom assessment |
| title | Observational study of omeprazole for gastroesophageal reflux on pulmonary function in adult asthmatics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T12%3A36%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Observational%20study%20of%20omeprazole%20for%20gastroesophageal%20reflux%20on%20pulmonary%20function%20in%20adult%20asthmatics&rft.jtitle=Asian%20biomedicine&rft.au=Jaimchariyatam,%20Nattapong&rft.date=2017-01-31&rft.volume=9&rft.issue=2&rft.spage=139&rft.epage=145&rft.pages=139-145&rft.issn=1875-855X&rft.eissn=1875-855X&rft_id=info:doi/10.5372/1905-7415.0902.379&rft_dat=%3Cproquest_cross%3E3153889090%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3153889090&rft_id=info:pmid/&rfr_iscdi=true |