Branched Linkers for Homogeneous Antibody-Drug Conjugates: How Long Is Long Enough?

Homogeneous antibody–drug conjugates (ADCs) exhibit significantly improved pharmacological properties compared to their heterogeneous counterparts. Site-specific conjugation of the payload to the IgG required for homogeneity can be achieved using enzymes. One example is microbial transglutaminase (M...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (24), p.13356
Hauptverfasser:	Gulyak, Evgeny L, Komarova, Olga A, Prokopenko, Yury A, Faizullina, Elina A, Malabuiok, Diana M, Ibragimova, Aigul R, Mokrushina, Yuliana A, Serova, Oxana V, Popova, Galina P, Zhitlov, Mikhail Y, Nikitin, Timofei D, Brylev, Vladimir A, Ustinov, Alexey V, Alferova, Vera A, Korshun, Vladimir A, Smirnov, Ivan V, Terekhov, Stanislav S, Sapozhnikova, Ksenia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Biopharmaceutics Cancer Chemical bonds Clinical trials Comparative analysis Drugs Enzymes Genetic engineering Immunoglobulin G Metastasis Pharmaceutical industry Thiols Trends
Online-Zugang:	Volltext
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