Enhanced Pain Reduction at Different Stages of Knee Osteoarthritis via Repeated Injections of Hyaluronic Acid with Niacinamide: A Comparative Study
Osteoarthritis (OA) of the knee is the most common joint disease, characterized by the degeneration of joint cartilage. Intra-articular hyaluronic acid (IAHA) injections are a well-established non-surgical treatment. This retrospective study analyzed knee OA patients receiving IAHA combined with nia...
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| Veröffentlicht in: | Journal of clinical medicine 2024-12, Vol.13 (24), p.7553 |
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| creator | Pennekamp, Sophie Hegelmaier, Stephan Hitzl, Wolfgang Geßlein, Markus Bail, Hermann Josef Loose, Kim Kopf, Andreas Engel, Niklas Rüther, Johannes Willauschus, Maximilian Millrose, Michael |
| description | Osteoarthritis (OA) of the knee is the most common joint disease, characterized by the degeneration of joint cartilage. Intra-articular hyaluronic acid (IAHA) injections are a well-established non-surgical treatment.
This retrospective study analyzed knee OA patients receiving IAHA combined with niacinamide injections, assessing pain reduction in relation to patient data, the number of injections, and radiological findings.
IAHA injections led to significant pain reduction on the numeric rating scale (NRS) (0-10), with a mean decrease of 3.34 ± 1.65. Pain relief was greater with multiple injections. A comparison of subgroups by injection frequency (1, 2, or >2) showed significant pain reduction between 1 and 2 injections (
= 0.027) and between 1 and >2 injections (
= 0.032). The OA grade measured using the Kellgren-Lawrence (
= 0.95) and Vallotton MRI classifications (
= 0.50) did not correlate with pain reduction. However, patients with meniscal damage (
= 0.02) showed a greater benefit. A strong positive correlation was found between baseline pain intensity and pain reduction (
< 0.001; r = 0.61).
IAHA with niacinamide significantly reduces knee OA pain, with more injections enhancing pain relief. Greater benefits were observed in patients with higher baseline pain and meniscal damage. The favorable safety profile and potential for repeated treatments make IAHA a valuable option in knee OA management. |
| doi_str_mv | 10.3390/jcm13247553 |
| format | Article |
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This retrospective study analyzed knee OA patients receiving IAHA combined with niacinamide injections, assessing pain reduction in relation to patient data, the number of injections, and radiological findings.
IAHA injections led to significant pain reduction on the numeric rating scale (NRS) (0-10), with a mean decrease of 3.34 ± 1.65. Pain relief was greater with multiple injections. A comparison of subgroups by injection frequency (1, 2, or >2) showed significant pain reduction between 1 and 2 injections (
= 0.027) and between 1 and >2 injections (
= 0.032). The OA grade measured using the Kellgren-Lawrence (
= 0.95) and Vallotton MRI classifications (
= 0.50) did not correlate with pain reduction. However, patients with meniscal damage (
= 0.02) showed a greater benefit. A strong positive correlation was found between baseline pain intensity and pain reduction (
< 0.001; r = 0.61).
IAHA with niacinamide significantly reduces knee OA pain, with more injections enhancing pain relief. Greater benefits were observed in patients with higher baseline pain and meniscal damage. The favorable safety profile and potential for repeated treatments make IAHA a valuable option in knee OA management.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13247553</identifier><identifier>PMID: 39768476</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Body mass index ; Bone marrow ; Care and treatment ; Cartilage ; Classification ; Health aspects ; Hyaluronic acid ; Knee ; Magnetic resonance imaging ; Niacinamide ; Osteoarthritis ; Overweight ; Pain ; Patients ; Physiology ; Statistical analysis ; X-rays</subject><ispartof>Journal of clinical medicine, 2024-12, Vol.13 (24), p.7553</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c365t-d3d36b53ab24489e40db771166fc59c2f5d66945ef599f672ed7c0bb60caff8a3</cites><orcidid>0000-0002-7696-1479 ; 0009-0009-0901-3928 ; 0000-0002-8856-6441 ; 0000-0001-6899-7757 ; 0000-0002-7010-8450 ; 0000-0003-1267-200X ; 0000-0003-3863-1580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39768476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pennekamp, Sophie</creatorcontrib><creatorcontrib>Hegelmaier, Stephan</creatorcontrib><creatorcontrib>Hitzl, Wolfgang</creatorcontrib><creatorcontrib>Geßlein, Markus</creatorcontrib><creatorcontrib>Bail, Hermann Josef</creatorcontrib><creatorcontrib>Loose, Kim</creatorcontrib><creatorcontrib>Kopf, Andreas</creatorcontrib><creatorcontrib>Engel, Niklas</creatorcontrib><creatorcontrib>Rüther, Johannes</creatorcontrib><creatorcontrib>Willauschus, Maximilian</creatorcontrib><creatorcontrib>Millrose, Michael</creatorcontrib><title>Enhanced Pain Reduction at Different Stages of Knee Osteoarthritis via Repeated Injections of Hyaluronic Acid with Niacinamide: A Comparative Study</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Osteoarthritis (OA) of the knee is the most common joint disease, characterized by the degeneration of joint cartilage. Intra-articular hyaluronic acid (IAHA) injections are a well-established non-surgical treatment.
This retrospective study analyzed knee OA patients receiving IAHA combined with niacinamide injections, assessing pain reduction in relation to patient data, the number of injections, and radiological findings.
IAHA injections led to significant pain reduction on the numeric rating scale (NRS) (0-10), with a mean decrease of 3.34 ± 1.65. Pain relief was greater with multiple injections. A comparison of subgroups by injection frequency (1, 2, or >2) showed significant pain reduction between 1 and 2 injections (
= 0.027) and between 1 and >2 injections (
= 0.032). The OA grade measured using the Kellgren-Lawrence (
= 0.95) and Vallotton MRI classifications (
= 0.50) did not correlate with pain reduction. However, patients with meniscal damage (
= 0.02) showed a greater benefit. A strong positive correlation was found between baseline pain intensity and pain reduction (
< 0.001; r = 0.61).
IAHA with niacinamide significantly reduces knee OA pain, with more injections enhancing pain relief. Greater benefits were observed in patients with higher baseline pain and meniscal damage. The favorable safety profile and potential for repeated treatments make IAHA a valuable option in knee OA management.</description><subject>Body mass index</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Cartilage</subject><subject>Classification</subject><subject>Health aspects</subject><subject>Hyaluronic acid</subject><subject>Knee</subject><subject>Magnetic resonance imaging</subject><subject>Niacinamide</subject><subject>Osteoarthritis</subject><subject>Overweight</subject><subject>Pain</subject><subject>Patients</subject><subject>Physiology</subject><subject>Statistical analysis</subject><subject>X-rays</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1v1DAQhiMEolXpiTuyxAUJbYnjxE64oNVSaEVFER9na2KPd71K7MV2Fu3v4A_jbUu1RdgHj-znfUfjmaJ4TsszxrryzVqNlFW1aBr2qDiuSiFmJWvZ44P4qDiNcV3m1bZ1RcXT4oh1gre14MfF73O3AqdQky9gHfmKelLJekcgkffWGAzoEvmWYImReEM-OURyHRN6CGkVbLKRbC1k4QYhZZtLt8Ybhxv8YgfDFLyzisyV1eSXTSvy2YKyDkar8S2Zk4UfNxAg2S3mRJPePSueGBgint6dJ8WPD-ffFxezq-uPl4v51Uwx3qSZZprxvmHQV3XddliXuheCUs6NajpVmUZz3tUNmqbrDBcVaqHKvuelAmNaYCfFu1vfzdSPqFWuNMAgN8GOEHbSg5UPX5xdyaXfSkpF1ZZVlx1e3TkE_3PCmORoo8JhAId-ipLR3JeG15Rn9OU_6NpPweX6MlV3vM7tOKCWMKC0zvicWO1N5bytaMsEFXvq7D9U3hpHq7xDY_P9A8HrW4EKPsaA5r5IWsr9HMmDOcr0i8N_uWf_Tg37A-zAw9M</recordid><startdate>20241212</startdate><enddate>20241212</enddate><creator>Pennekamp, Sophie</creator><creator>Hegelmaier, Stephan</creator><creator>Hitzl, Wolfgang</creator><creator>Geßlein, Markus</creator><creator>Bail, Hermann Josef</creator><creator>Loose, Kim</creator><creator>Kopf, Andreas</creator><creator>Engel, Niklas</creator><creator>Rüther, Johannes</creator><creator>Willauschus, Maximilian</creator><creator>Millrose, Michael</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7696-1479</orcidid><orcidid>https://orcid.org/0009-0009-0901-3928</orcidid><orcidid>https://orcid.org/0000-0002-8856-6441</orcidid><orcidid>https://orcid.org/0000-0001-6899-7757</orcidid><orcidid>https://orcid.org/0000-0002-7010-8450</orcidid><orcidid>https://orcid.org/0000-0003-1267-200X</orcidid><orcidid>https://orcid.org/0000-0003-3863-1580</orcidid></search><sort><creationdate>20241212</creationdate><title>Enhanced Pain Reduction at Different Stages of Knee Osteoarthritis via Repeated Injections of Hyaluronic Acid with Niacinamide: A Comparative Study</title><author>Pennekamp, Sophie ; 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Intra-articular hyaluronic acid (IAHA) injections are a well-established non-surgical treatment.
This retrospective study analyzed knee OA patients receiving IAHA combined with niacinamide injections, assessing pain reduction in relation to patient data, the number of injections, and radiological findings.
IAHA injections led to significant pain reduction on the numeric rating scale (NRS) (0-10), with a mean decrease of 3.34 ± 1.65. Pain relief was greater with multiple injections. A comparison of subgroups by injection frequency (1, 2, or >2) showed significant pain reduction between 1 and 2 injections (
= 0.027) and between 1 and >2 injections (
= 0.032). The OA grade measured using the Kellgren-Lawrence (
= 0.95) and Vallotton MRI classifications (
= 0.50) did not correlate with pain reduction. However, patients with meniscal damage (
= 0.02) showed a greater benefit. A strong positive correlation was found between baseline pain intensity and pain reduction (
< 0.001; r = 0.61).
IAHA with niacinamide significantly reduces knee OA pain, with more injections enhancing pain relief. Greater benefits were observed in patients with higher baseline pain and meniscal damage. The favorable safety profile and potential for repeated treatments make IAHA a valuable option in knee OA management.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39768476</pmid><doi>10.3390/jcm13247553</doi><orcidid>https://orcid.org/0000-0002-7696-1479</orcidid><orcidid>https://orcid.org/0009-0009-0901-3928</orcidid><orcidid>https://orcid.org/0000-0002-8856-6441</orcidid><orcidid>https://orcid.org/0000-0001-6899-7757</orcidid><orcidid>https://orcid.org/0000-0002-7010-8450</orcidid><orcidid>https://orcid.org/0000-0003-1267-200X</orcidid><orcidid>https://orcid.org/0000-0003-3863-1580</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Body mass index Bone marrow Care and treatment Cartilage Classification Health aspects Hyaluronic acid Knee Magnetic resonance imaging Niacinamide Osteoarthritis Overweight Pain Patients Physiology Statistical analysis X-rays |
| title | Enhanced Pain Reduction at Different Stages of Knee Osteoarthritis via Repeated Injections of Hyaluronic Acid with Niacinamide: A Comparative Study |
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