Azobenzene-Based Voltage-Gated Sodium Channel Blockers with Light-Controlled Local Anesthetic and Antiarrhythmic Activity

The work is devoted to the synthesis of new light-controlled voltage-gated sodium (Na v ) channel blockers based on azobenzene and the study of their local anesthetic and antiarrhythmic properties. The effect of ethercaine and two of its new derivatives on native Na v channels was studied in vitro u...

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Veröffentlicht in:	Biophysics (Oxford) 2024, Vol.69 (3), p.485-503
Hauptverfasser:	Noev, A. N., Kovalenko, S. G., Gataulina, E. D., Turchaninova, E. A., Dzhabrailov, V. D., Aitova, A. A., Likhobabina, D. A., Sutemieva, J. A., Frolova, S. R., Ruppel, L. E., Minakov, D. A., Suvorov, N. V., Ostroverkhov, P. V., Vasil’ev, Yu. L., Nikolaev, M. V., Tsvelaya, V. A., Agladze, K. I., Grin, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Arrhythmia Biological activity Biological and Medical Physics Biophysics Cardiomyocytes Cell Biophysics Channel gating Cornea Physics Physics and Astronomy Sodium channels (voltage-gated)
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