Immunohistochemical Study of Nerve Growth Factor Expression in Hansen’s Disease
Aim: To study the immunoexpression of nerve growth factor (NGF) in Hansen's disease to assess the diagnostic and prognostic significance. Objective: NGF is a neurotrophin and an important growth factor for the tissue remodeling process. Higher expression of NGF is observed in the lepromatous fo...
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| Veröffentlicht in: | Indian journal of dermatopathology and diagnostic dermatology 2024-07, Vol.11 (2), p.41-45 |
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| creator | Lubna, Fatma Abbas, Aijaz Adil, Mohammad Akhtar, Kafil |
| description | Aim: To study the immunoexpression of nerve growth factor (NGF) in Hansen's disease to assess the diagnostic and prognostic significance. Objective: NGF is a neurotrophin and an important growth factor for the tissue remodeling process. Higher expression of NGF is observed in the lepromatous forms when compared to tuberculoid forms. Materials and Methods: The present prospective study was carried out in the Departments of Pathology and Dermatology at Aligarh Muslim University, Aligarh, Uttar Pradesh, India, in 50 patients of Hansen's disease. Results: The study included 50 cases of Hansen's disease. The majority of the cases were of borderline lepromatous, 15 (30.0%), followed by 12 (24.0%) cases each of borderline tuberculoid and tuberculoid leprosy. Higher staining intensity of NGF and a higher percentage of positive cells were observed in lepromatous leprosy (LL) cases as compared to tuberculoid leprosy (TT) cases. The highest number of cases with a high immunoreactivity score (IRS) was of LL, whereas TT cases showed a low IRS. Conclusion: The immunoexpression of NGF was more intense on the lepromatous side of the spectrum compared to the tuberculoid side, indicating the severity of the disease with less potential for cure. Keywords: Hansen's disease, immunohistochemistry, lepromatous, nerve growth factor |
| doi_str_mv | 10.4103/ijdpdd.ijdpdd_7_24 |
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Objective: NGF is a neurotrophin and an important growth factor for the tissue remodeling process. Higher expression of NGF is observed in the lepromatous forms when compared to tuberculoid forms. Materials and Methods: The present prospective study was carried out in the Departments of Pathology and Dermatology at Aligarh Muslim University, Aligarh, Uttar Pradesh, India, in 50 patients of Hansen's disease. Results: The study included 50 cases of Hansen's disease. The majority of the cases were of borderline lepromatous, 15 (30.0%), followed by 12 (24.0%) cases each of borderline tuberculoid and tuberculoid leprosy. Higher staining intensity of NGF and a higher percentage of positive cells were observed in lepromatous leprosy (LL) cases as compared to tuberculoid leprosy (TT) cases. The highest number of cases with a high immunoreactivity score (IRS) was of LL, whereas TT cases showed a low IRS. Conclusion: The immunoexpression of NGF was more intense on the lepromatous side of the spectrum compared to the tuberculoid side, indicating the severity of the disease with less potential for cure. Keywords: Hansen's disease, immunohistochemistry, lepromatous, nerve growth factor</description><identifier>ISSN: 2349-6029</identifier><identifier>EISSN: 2349-6029</identifier><identifier>DOI: 10.4103/ijdpdd.ijdpdd_7_24</identifier><language>eng</language><publisher>Mumbai: Medknow Publications and Media Pvt. Ltd</publisher><subject>Diseases ; Growth factors ; hansen’s disease ; Immunohistochemistry ; India ; Islamic schools ; lepromatous ; Leprosy ; Medical research ; Medicine, Experimental ; Nerve growth factor</subject><ispartof>Indian journal of dermatopathology and diagnostic dermatology, 2024-07, Vol.11 (2), p.41-45</ispartof><rights>COPYRIGHT 2024 Medknow Publications and Media Pvt. Ltd.</rights><rights>2024. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2357-ca48de4a330d8f89649d9f77b0c0af463a0611133ff7de2ef3189a7b38c30e073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2096,27901,27902</link.rule.ids></links><search><creatorcontrib>Lubna, Fatma</creatorcontrib><creatorcontrib>Abbas, Aijaz</creatorcontrib><creatorcontrib>Adil, Mohammad</creatorcontrib><creatorcontrib>Akhtar, Kafil</creatorcontrib><title>Immunohistochemical Study of Nerve Growth Factor Expression in Hansen’s Disease</title><title>Indian journal of dermatopathology and diagnostic dermatology</title><description>Aim: To study the immunoexpression of nerve growth factor (NGF) in Hansen's disease to assess the diagnostic and prognostic significance. Objective: NGF is a neurotrophin and an important growth factor for the tissue remodeling process. Higher expression of NGF is observed in the lepromatous forms when compared to tuberculoid forms. Materials and Methods: The present prospective study was carried out in the Departments of Pathology and Dermatology at Aligarh Muslim University, Aligarh, Uttar Pradesh, India, in 50 patients of Hansen's disease. Results: The study included 50 cases of Hansen's disease. The majority of the cases were of borderline lepromatous, 15 (30.0%), followed by 12 (24.0%) cases each of borderline tuberculoid and tuberculoid leprosy. Higher staining intensity of NGF and a higher percentage of positive cells were observed in lepromatous leprosy (LL) cases as compared to tuberculoid leprosy (TT) cases. The highest number of cases with a high immunoreactivity score (IRS) was of LL, whereas TT cases showed a low IRS. Conclusion: The immunoexpression of NGF was more intense on the lepromatous side of the spectrum compared to the tuberculoid side, indicating the severity of the disease with less potential for cure. Keywords: Hansen's disease, immunohistochemistry, lepromatous, nerve growth factor</description><subject>Diseases</subject><subject>Growth factors</subject><subject>hansen’s disease</subject><subject>Immunohistochemistry</subject><subject>India</subject><subject>Islamic schools</subject><subject>lepromatous</subject><subject>Leprosy</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nerve growth factor</subject><issn>2349-6029</issn><issn>2349-6029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptks9q3DAQxk1poCHNC-RkKPS225FGsaRjSPNnIbSUJmehlUaxFtvaSnbb3Poafb0-SZ1uaDdQ5jDD8M0P6eOrqhMGS8EA38WN33q_3DUjDRcvqkOOQi8a4Prl3vyqOi5lAwBMKdAoDqtPq76fhtTGMibXUh-d7erP4-Qf6hTqD5S_Un2V07exrS-tG1OuL75vM5US01DHob62Q6Hh14-fpX4fC9lCr6uDYLtCx0_9qLq7vLg9v17cfLxanZ_dLBzHU7lwVihPwiKCV0HpRmivg5RrcGCDaNBCwxhDDEF64hSQKW3lGpVDIJB4VK12XJ_sxmxz7G1-MMlG82eR8r2xeYyuIzMzhNWcS-bk7BjXawYaiKF2nNEaZ9abHWub05eJymg2acrD_HyDTDRan4KS_1T3dobGIaQxW9fH4syZ4giICsSsWv5HNZd_dDcNFOK8f3bwdu-gJduNbUndNM4Wl-dCvhO6nErJFP7-moF5TIJ5isBeEvA3G9ynuQ</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Lubna, Fatma</creator><creator>Abbas, Aijaz</creator><creator>Adil, Mohammad</creator><creator>Akhtar, Kafil</creator><general>Medknow Publications and Media Pvt. 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Objective: NGF is a neurotrophin and an important growth factor for the tissue remodeling process. Higher expression of NGF is observed in the lepromatous forms when compared to tuberculoid forms. Materials and Methods: The present prospective study was carried out in the Departments of Pathology and Dermatology at Aligarh Muslim University, Aligarh, Uttar Pradesh, India, in 50 patients of Hansen's disease. Results: The study included 50 cases of Hansen's disease. The majority of the cases were of borderline lepromatous, 15 (30.0%), followed by 12 (24.0%) cases each of borderline tuberculoid and tuberculoid leprosy. Higher staining intensity of NGF and a higher percentage of positive cells were observed in lepromatous leprosy (LL) cases as compared to tuberculoid leprosy (TT) cases. The highest number of cases with a high immunoreactivity score (IRS) was of LL, whereas TT cases showed a low IRS. Conclusion: The immunoexpression of NGF was more intense on the lepromatous side of the spectrum compared to the tuberculoid side, indicating the severity of the disease with less potential for cure. Keywords: Hansen's disease, immunohistochemistry, lepromatous, nerve growth factor</abstract><cop>Mumbai</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><doi>10.4103/ijdpdd.ijdpdd_7_24</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Diseases Growth factors hansen’s disease Immunohistochemistry India Islamic schools lepromatous Leprosy Medical research Medicine, Experimental Nerve growth factor |
| title | Immunohistochemical Study of Nerve Growth Factor Expression in Hansen’s Disease |
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