DPF2 reads histone lactylation to drive transcription and tumorigenesis

Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins. Here, we observe that cervical ca...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-12, Vol.121 (50), p.e2421496121
Hauptverfasser:	Zhai, Guijin, Niu, Ziping, Jiang, Zixin, Zhao, Fei, Wang, Siyu, Chen, Chen, Zheng, Wei, Wang, Aiyuan, Zang, Yong, Han, Yanpu, Zhang, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carcinogenesis - genetics Carcinogenesis - metabolism Cell Line, Tumor Cell survival Cervical cancer DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene expression Gene Expression Regulation, Neoplastic Gene regulation Histones Histones - genetics Histones - metabolism Humans Lysine Lysine - metabolism Protein Processing, Post-Translational Proteomics Survival Transcription Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumorigenesis Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!