USP18-mediated protein stabilization of NOTCH1 is associated with altered Th17/Treg cell ratios and B cell-mediated autoantibody secretion in Sjögren syndrome

Sjögren Syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of exocrine glands. This study, based on bioinformatics predictions, investigates the biological functions of ubiquitin specific peptidase 18 (USP18) and notch receptor 1 (NOTCH1) in T helper...

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Veröffentlicht in:	Immunologic research 2024-12, Vol.73 (1), p.10
Hauptverfasser:	Jin, Xiaorong, Bai, Yunjing, Xu, Xiaohua, Wu, Fan, Long, Xiaoyu, Yao, Yajuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Autoantibodies Autoantibodies - immunology Autoantibodies - metabolism Autoimmune diseases B-Lymphocytes - immunology B-Lymphocytes - metabolism Bioinformatics Biomedical and Life Sciences Biomedicine Exocrine glands Female Helper cells Humans Immunology Infiltration Internal Medicine Leukocytes (mononuclear) Lymphocytes B Lymphocytes T Male Medicine/Public Health Mice Mice, Inbred NOD Middle Aged Notch protein Notch1 protein Peripheral blood mononuclear cells Protein Stability Proteins Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Sjogren's syndrome Sjogren's Syndrome - immunology Sjogren's Syndrome - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Ubiquitin Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitination Up-regulation USP18 protein
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