Glioma-Derived Exosomes and Their Application as Drug Nanoparticles
Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2024-12, Vol.25 (23), p.12524 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 23 |
| container_start_page | 12524 |
| container_title | International journal of molecular sciences |
| container_volume | 25 |
| creator | Mastantuono, Serena Manini, Ivana Di Loreto, Carla Beltrami, Antonio Paolo Vindigni, Marco Cesselli, Daniela |
| description | Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes. Glioma-Derived Exosomes (GDEs) work, indeed, as potent signaling particles promoting the progression of brain tumors by inducing tumor proliferation, invasion, migration, angiogenesis and resistance to chemotherapy or radiation. Given their nanoscale size, exosomes can cross the blood–brain barrier (BBB), thus becoming not only a promising biomarker to predict diagnosis and prognosis but also a therapeutic target to treat GBM. In this review, we describe the structural and functional characteristics of exosomes and their involvement in GBM development, diagnosis, prognosis and treatment. In addition, we discuss how exosomes can be modified to be used as a therapeutic target/drug delivery system for clinical applications. |
| doi_str_mv | 10.3390/ijms252312524 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3144197424</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3144197424</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1054-65c0a24b8d8fc3b4bd8dcfc6a5c4b6ed0a9df7b6c6edf9fb2d4ac502189dec683</originalsourceid><addsrcrecordid>eNpVkD1PwzAYhC0EEqUwsltiDvgrHx6rthSkCpYyW85rGxwlcbATBP-eoDLAcnfDozvpELqm5JZzSe580yWWM05nESdoQQVjGSFFefonn6OLlBpCGGe5XKD1rvWh09nGRv9hDd5-hhQ6m7DuDT68WR_xahhaD3r0occ64U2cXvGT7sOg4-ihtekSnTndJnv160v0cr89rB-y_fPucb3aZ0BJLrIiB6KZqCtTOeC1qE1lwEGhcxB1YQ3R0riyLmDOTrqaGaEhJ4xW0lgoKr5EN8feIYb3yaZRNWGK_TypOBWCylIwMVPZkYIYUorWqSH6TscvRYn6-Un9-4l_AzkNXD4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3144197424</pqid></control><display><type>article</type><title>Glioma-Derived Exosomes and Their Application as Drug Nanoparticles</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Mastantuono, Serena ; Manini, Ivana ; Di Loreto, Carla ; Beltrami, Antonio Paolo ; Vindigni, Marco ; Cesselli, Daniela</creator><creatorcontrib>Mastantuono, Serena ; Manini, Ivana ; Di Loreto, Carla ; Beltrami, Antonio Paolo ; Vindigni, Marco ; Cesselli, Daniela</creatorcontrib><description>Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes. Glioma-Derived Exosomes (GDEs) work, indeed, as potent signaling particles promoting the progression of brain tumors by inducing tumor proliferation, invasion, migration, angiogenesis and resistance to chemotherapy or radiation. Given their nanoscale size, exosomes can cross the blood–brain barrier (BBB), thus becoming not only a promising biomarker to predict diagnosis and prognosis but also a therapeutic target to treat GBM. In this review, we describe the structural and functional characteristics of exosomes and their involvement in GBM development, diagnosis, prognosis and treatment. In addition, we discuss how exosomes can be modified to be used as a therapeutic target/drug delivery system for clinical applications.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252312524</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Angiogenesis ; Apoptosis ; Biosynthesis ; Cancer ; Communication ; Drug resistance ; Extracellular matrix ; Extracellular vesicles ; Glioma ; Kinases ; Ligands ; Medical prognosis ; Metastasis ; Motility ; Physiology ; Plasma ; Proteins ; Stem cells ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2024-12, Vol.25 (23), p.12524</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1054-65c0a24b8d8fc3b4bd8dcfc6a5c4b6ed0a9df7b6c6edf9fb2d4ac502189dec683</cites><orcidid>0000-0002-0562-7852 ; 0000-0002-0679-2710</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids></links><search><creatorcontrib>Mastantuono, Serena</creatorcontrib><creatorcontrib>Manini, Ivana</creatorcontrib><creatorcontrib>Di Loreto, Carla</creatorcontrib><creatorcontrib>Beltrami, Antonio Paolo</creatorcontrib><creatorcontrib>Vindigni, Marco</creatorcontrib><creatorcontrib>Cesselli, Daniela</creatorcontrib><title>Glioma-Derived Exosomes and Their Application as Drug Nanoparticles</title><title>International journal of molecular sciences</title><description>Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes. Glioma-Derived Exosomes (GDEs) work, indeed, as potent signaling particles promoting the progression of brain tumors by inducing tumor proliferation, invasion, migration, angiogenesis and resistance to chemotherapy or radiation. Given their nanoscale size, exosomes can cross the blood–brain barrier (BBB), thus becoming not only a promising biomarker to predict diagnosis and prognosis but also a therapeutic target to treat GBM. In this review, we describe the structural and functional characteristics of exosomes and their involvement in GBM development, diagnosis, prognosis and treatment. In addition, we discuss how exosomes can be modified to be used as a therapeutic target/drug delivery system for clinical applications.</description><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biosynthesis</subject><subject>Cancer</subject><subject>Communication</subject><subject>Drug resistance</subject><subject>Extracellular matrix</subject><subject>Extracellular vesicles</subject><subject>Glioma</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Motility</subject><subject>Physiology</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Stem cells</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkD1PwzAYhC0EEqUwsltiDvgrHx6rthSkCpYyW85rGxwlcbATBP-eoDLAcnfDozvpELqm5JZzSe580yWWM05nESdoQQVjGSFFefonn6OLlBpCGGe5XKD1rvWh09nGRv9hDd5-hhQ6m7DuDT68WR_xahhaD3r0occ64U2cXvGT7sOg4-ihtekSnTndJnv160v0cr89rB-y_fPucb3aZ0BJLrIiB6KZqCtTOeC1qE1lwEGhcxB1YQ3R0riyLmDOTrqaGaEhJ4xW0lgoKr5EN8feIYb3yaZRNWGK_TypOBWCylIwMVPZkYIYUorWqSH6TscvRYn6-Un9-4l_AzkNXD4</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Mastantuono, Serena</creator><creator>Manini, Ivana</creator><creator>Di Loreto, Carla</creator><creator>Beltrami, Antonio Paolo</creator><creator>Vindigni, Marco</creator><creator>Cesselli, Daniela</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-0562-7852</orcidid><orcidid>https://orcid.org/0000-0002-0679-2710</orcidid></search><sort><creationdate>20241201</creationdate><title>Glioma-Derived Exosomes and Their Application as Drug Nanoparticles</title><author>Mastantuono, Serena ; Manini, Ivana ; Di Loreto, Carla ; Beltrami, Antonio Paolo ; Vindigni, Marco ; Cesselli, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1054-65c0a24b8d8fc3b4bd8dcfc6a5c4b6ed0a9df7b6c6edf9fb2d4ac502189dec683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Biosynthesis</topic><topic>Cancer</topic><topic>Communication</topic><topic>Drug resistance</topic><topic>Extracellular matrix</topic><topic>Extracellular vesicles</topic><topic>Glioma</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Motility</topic><topic>Physiology</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Stem cells</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mastantuono, Serena</creatorcontrib><creatorcontrib>Manini, Ivana</creatorcontrib><creatorcontrib>Di Loreto, Carla</creatorcontrib><creatorcontrib>Beltrami, Antonio Paolo</creatorcontrib><creatorcontrib>Vindigni, Marco</creatorcontrib><creatorcontrib>Cesselli, Daniela</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mastantuono, Serena</au><au>Manini, Ivana</au><au>Di Loreto, Carla</au><au>Beltrami, Antonio Paolo</au><au>Vindigni, Marco</au><au>Cesselli, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glioma-Derived Exosomes and Their Application as Drug Nanoparticles</atitle><jtitle>International journal of molecular sciences</jtitle><date>2024-12-01</date><risdate>2024</risdate><volume>25</volume><issue>23</issue><spage>12524</spage><pages>12524-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Glioblastoma Multiforme (GBM) is the most aggressive primary tumor of the Central Nervous System (CNS) with a low survival rate. The malignancy of GBM is sustained by a bidirectional crosstalk between tumor cells and the Tumor Microenvironment (TME). This mechanism of intercellular communication is mediated, at least in part, by the release of exosomes. Glioma-Derived Exosomes (GDEs) work, indeed, as potent signaling particles promoting the progression of brain tumors by inducing tumor proliferation, invasion, migration, angiogenesis and resistance to chemotherapy or radiation. Given their nanoscale size, exosomes can cross the blood–brain barrier (BBB), thus becoming not only a promising biomarker to predict diagnosis and prognosis but also a therapeutic target to treat GBM. In this review, we describe the structural and functional characteristics of exosomes and their involvement in GBM development, diagnosis, prognosis and treatment. In addition, we discuss how exosomes can be modified to be used as a therapeutic target/drug delivery system for clinical applications.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/ijms252312524</doi><orcidid>https://orcid.org/0000-0002-0562-7852</orcidid><orcidid>https://orcid.org/0000-0002-0679-2710</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2024-12, Vol.25 (23), p.12524 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_proquest_journals_3144197424 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Angiogenesis Apoptosis Biosynthesis Cancer Communication Drug resistance Extracellular matrix Extracellular vesicles Glioma Kinases Ligands Medical prognosis Metastasis Motility Physiology Plasma Proteins Stem cells Tumor necrosis factor-TNF |
| title | Glioma-Derived Exosomes and Their Application as Drug Nanoparticles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A25%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glioma-Derived%20Exosomes%20and%20Their%20Application%20as%20Drug%20Nanoparticles&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Mastantuono,%20Serena&rft.date=2024-12-01&rft.volume=25&rft.issue=23&rft.spage=12524&rft.pages=12524-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms252312524&rft_dat=%3Cproquest_cross%3E3144197424%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3144197424&rft_id=info:pmid/&rfr_iscdi=true |