The Role of PD-1/PD-L1 and IL-7 in Lymphocyte Dynamics and Sepsis Progression: A Biomarker Study in Critically Ill Patients

Sepsis pathophysiology involves a dysregulated immune response to infection, excessive inflammation, and immune paralysis. This study explores the relationships between cell death biomarkers (serum-soluble levels of programmed cell death protein 1 (PD-1), programmed death ligand 1 (PD-L1), and inter...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12612
Hauptverfasser:	Coman, Oana, Grigorescu, Bianca-Liana, Huțanu, Adina, Bacârea, Anca, Văsieșiu, Anca Meda, Fodor, Raluca Ștefania, Petrișor, Marius, Azamfirei, Leonard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis B cells B7-H1 Antigen - blood B7-H1 Antigen - metabolism Biomarkers Biomarkers - blood Cell death Critical Illness Cytokines Cytotoxicity Development and progression Diagnosis Disease Progression Female Health aspects Humans Immune response Infection Inflammation Intensive care Interleukin-7 - blood Interleukin-7 - metabolism Interleukins Ligands Lymphocytes Lymphocytes - immunology Lymphocytes - metabolism Male Medical research Medicine, Experimental Middle Aged Mortality Pathogens Pathophysiology Programmed Cell Death 1 Receptor - metabolism Prospective Studies Sepsis Sepsis - blood Sepsis - immunology Sepsis - metabolism T cell receptors T cells
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