The Therapeutic Effects of SP-8356, a Verbenone Derivative, with Multimodal Cytoprotective Mechanisms in an Ischemic Stroke Rat Model

An ischemic cerebral stroke results from the interruption of blood flow to the brain, triggering rapid and complex cascades of excitotoxicity, oxidative stress, and inflammation. Current reperfusion therapies, including intravenous thrombolysis and mechanical thrombectomy, cause further brain injury...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12769
Hauptverfasser:	Song, Hwa Young, Jin, Sejong, Lee, Sekwang, Jalin, Angela Melinda Anthony, Roh, Kyung-Hye, Kim, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Atherosclerosis Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Cell adhesion & migration Cytokines Cytoprotection - drug effects Disease Models, Animal Drug dosages Edema Free radicals Infarction, Middle Cerebral Artery - drug therapy Inflammation Injuries Ischemia Ischemic Stroke - drug therapy Ischemic Stroke - pathology Leukocytes Male Medical colleges Medical prognosis Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neutrophils Oxidative stress Oxidative Stress - drug effects Permeability Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Tetracycline Tetracyclines Traumatic brain injury
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