Towards the generalized iterative synthesis of small molecules

Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the highly customized approach that is currently used to synthesize this class of chemical matter. An alternative ‘building block approach’ — that is,...

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Veröffentlicht in:Nature reviews. Chemistry 2018-02, Vol.2 (2), p.0115, Article 0115
Hauptverfasser: Lehmann, Jonathan W., Blair, Daniel J., Burke, Martin D.
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Burke, Martin D.
description Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the highly customized approach that is currently used to synthesize this class of chemical matter. An alternative ‘building block approach’ — that is, generalized iterative assembly of interchangeable parts — has now proved to be a highly efficient and flexible method of constructing things ranging from skyscrapers and macromolecules to artificial intelligence algorithms. The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that already improve access to specific classes of small molecules. There has also been substantial recent progress towards the iterative assembly of many different types of small molecules, including complex natural products, pharmaceuticals, biological probes and materials, using common building blocks and coupling chemistry. Collectively, these advances suggest that a generalized building block approach for small-molecule synthesis may be within reach. Iterative approaches to synthesis have revolutionized the preparation and study of peptides, nucleic acids and sugars. This Review discusses whether and how such iterative syntheses can be applied more broadly towards an ultimate goal of developing a building block approach to the synthesis of most small organic molecules.
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subjects 639/638/549/933
639/638/549/973
639/638/549/977
Algorithms
Analytical Chemistry
Artificial intelligence
Assembly
Biochemistry
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Construction materials
Coupling (molecular)
Customization
Inorganic Chemistry
Macromolecules
Natural products
Nucleic acids
Organic Chemistry
Peptides
Physical Chemistry
Redundancy
review-article
Skyscrapers
Sugar
title Towards the generalized iterative synthesis of small molecules
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