Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate

Glucocorticosteroids (GCs) are widely used in the treatment of inflammatory skin diseases due to their anti-inflammatory, anti-proliferative, and immunosuppressive properties. However, long-term therapy with conventional GC formulations can lead to adverse effects, whose severity depends on dosage a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BioNanoScience 2025, Vol.15 (1)
Hauptverfasser: Demina, Polina A., Saveleva, Mariia S., Verkhovskii, Roman A., Anisimov, Roman A., Pidenko, Pavel S., Svenskaya, Yulia I.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 1
container_start_page
container_title BioNanoScience
container_volume 15
creator Demina, Polina A.
Saveleva, Mariia S.
Verkhovskii, Roman A.
Anisimov, Roman A.
Pidenko, Pavel S.
Svenskaya, Yulia I.
description Glucocorticosteroids (GCs) are widely used in the treatment of inflammatory skin diseases due to their anti-inflammatory, anti-proliferative, and immunosuppressive properties. However, long-term therapy with conventional GC formulations can lead to adverse effects, whose severity depends on dosage and duration of treatment. To address these issues, new approaches are being developed to increase the effectiveness of GC treatment and reduce side effects. These include the development of novel delivery systems for targeted drug delivery, efficient localization of GCs at the region of interest, and optimization of the release profile. In this study, we propose a promising system for the topical administration of betamethasone dipropionate (BD), one of the most commonly used GCs. A particulate formulation of this drug, based on micron-sized calcium carbonate (CaCO 3 ) carriers in vaterite form, has been developed. The loading capacity of this formulation was found to be almost 5% (w/w). The release of the drug from the carriers has been studied using a Franz diffusion cell. Surface modification of the BD-CaCO 3 carriers with multilayered polyelectrolyte coatings was performed in an effort to prolong the BD release. Deposition of biocompatible polymers, such as poly-L-arginine hydrochloride and dextran sulfate, was shown to be effective for the release profile optimization. The developed carriers demonstrated sufficient biocompatibility when incubated with L929 fibroblasts in vitro, providing evidence of safety for this particulate GC formulation. Our findings support the feasibility of controlling the GC release and optimizing the biological properties of BD-loaded carriers through surface modification paving the way for further tuning and optimization of the pharmaceutical properties of the proposed particulate formulation.
doi_str_mv 10.1007/s12668-024-01683-8
format Article
fullrecord <record><control><sourceid>proquest_sprin</sourceid><recordid>TN_cdi_proquest_journals_3141543291</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3141543291</sourcerecordid><originalsourceid>FETCH-LOGICAL-p157t-e75a1d15bb200f2d2a345d9d7d3839dbac5c3c74e4984e87871afda6c15c475e3</originalsourceid><addsrcrecordid>eNpFkE1PwzAMhiMEEtPYH-AUiXMhbpImPbLxKU0aQsC1yhp3y7S1XZKBxK8nUAS-2JYe-7VfQs6BXQJj6ipAXhQ6Y7nIGBSaZ_qIjHIoIYNClMd_NWenZBLChqVQrOCaj8j-sX3HEN3KRNe11LSWPuMWTUD65LvGbZEu-uh27nMAms7TNxPRu4jZNGGWzoz3Dn2g887Y1H-4uKZTjGaHcW1C1yK9cb3v-jSfJs_ISWO2ASe_eUxe725fZg_ZfHH_OLueZz1IFTNU0oAFuVzmjDW5zQ0X0pZW2XR3aZemljWvlUBRaoFaaQWmsaaoQdZCSeRjcjHsTdL7Q_qx2nQH3ybJioMAKXheQqL4QIXeu3aF_p8CVn3bWw32Vsne6sfeSvMvZ4lvQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3141543291</pqid></control><display><type>article</type><title>Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate</title><source>SpringerLink Journals - AutoHoldings</source><creator>Demina, Polina A. ; Saveleva, Mariia S. ; Verkhovskii, Roman A. ; Anisimov, Roman A. ; Pidenko, Pavel S. ; Svenskaya, Yulia I.</creator><creatorcontrib>Demina, Polina A. ; Saveleva, Mariia S. ; Verkhovskii, Roman A. ; Anisimov, Roman A. ; Pidenko, Pavel S. ; Svenskaya, Yulia I.</creatorcontrib><description>Glucocorticosteroids (GCs) are widely used in the treatment of inflammatory skin diseases due to their anti-inflammatory, anti-proliferative, and immunosuppressive properties. However, long-term therapy with conventional GC formulations can lead to adverse effects, whose severity depends on dosage and duration of treatment. To address these issues, new approaches are being developed to increase the effectiveness of GC treatment and reduce side effects. These include the development of novel delivery systems for targeted drug delivery, efficient localization of GCs at the region of interest, and optimization of the release profile. In this study, we propose a promising system for the topical administration of betamethasone dipropionate (BD), one of the most commonly used GCs. A particulate formulation of this drug, based on micron-sized calcium carbonate (CaCO 3 ) carriers in vaterite form, has been developed. The loading capacity of this formulation was found to be almost 5% (w/w). The release of the drug from the carriers has been studied using a Franz diffusion cell. Surface modification of the BD-CaCO 3 carriers with multilayered polyelectrolyte coatings was performed in an effort to prolong the BD release. Deposition of biocompatible polymers, such as poly-L-arginine hydrochloride and dextran sulfate, was shown to be effective for the release profile optimization. The developed carriers demonstrated sufficient biocompatibility when incubated with L929 fibroblasts in vitro, providing evidence of safety for this particulate GC formulation. Our findings support the feasibility of controlling the GC release and optimizing the biological properties of BD-loaded carriers through surface modification paving the way for further tuning and optimization of the pharmaceutical properties of the proposed particulate formulation.</description><identifier>ISSN: 2191-1630</identifier><identifier>EISSN: 2191-1649</identifier><identifier>DOI: 10.1007/s12668-024-01683-8</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arginine ; Biocompatibility ; Biological and Medical Physics ; Biological properties ; Biomaterials ; Biophysics ; Calcium carbonate ; Circuits and Systems ; Dextran ; Dextran sulfate ; Dextrans ; Diffusion cells ; Diffusion coatings ; Drug delivery ; Drug delivery systems ; Engineering ; Glucocorticoids ; Immunosuppressive agents ; Localization ; Nanotechnology ; Optimization ; Polyelectrolytes ; Side effects ; Skin diseases ; System effectiveness</subject><ispartof>BioNanoScience, 2025, Vol.15 (1)</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>Copyright Springer Nature B.V. 2025</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7771-0957 ; 0000-0002-9203-582X ; 0000-0003-2021-0462 ; 0000-0002-7787-3948 ; 0000-0002-6359-2969 ; 0000-0003-1830-4582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12668-024-01683-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12668-024-01683-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Demina, Polina A.</creatorcontrib><creatorcontrib>Saveleva, Mariia S.</creatorcontrib><creatorcontrib>Verkhovskii, Roman A.</creatorcontrib><creatorcontrib>Anisimov, Roman A.</creatorcontrib><creatorcontrib>Pidenko, Pavel S.</creatorcontrib><creatorcontrib>Svenskaya, Yulia I.</creatorcontrib><title>Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate</title><title>BioNanoScience</title><addtitle>BioNanoSci</addtitle><description>Glucocorticosteroids (GCs) are widely used in the treatment of inflammatory skin diseases due to their anti-inflammatory, anti-proliferative, and immunosuppressive properties. However, long-term therapy with conventional GC formulations can lead to adverse effects, whose severity depends on dosage and duration of treatment. To address these issues, new approaches are being developed to increase the effectiveness of GC treatment and reduce side effects. These include the development of novel delivery systems for targeted drug delivery, efficient localization of GCs at the region of interest, and optimization of the release profile. In this study, we propose a promising system for the topical administration of betamethasone dipropionate (BD), one of the most commonly used GCs. A particulate formulation of this drug, based on micron-sized calcium carbonate (CaCO 3 ) carriers in vaterite form, has been developed. The loading capacity of this formulation was found to be almost 5% (w/w). The release of the drug from the carriers has been studied using a Franz diffusion cell. Surface modification of the BD-CaCO 3 carriers with multilayered polyelectrolyte coatings was performed in an effort to prolong the BD release. Deposition of biocompatible polymers, such as poly-L-arginine hydrochloride and dextran sulfate, was shown to be effective for the release profile optimization. The developed carriers demonstrated sufficient biocompatibility when incubated with L929 fibroblasts in vitro, providing evidence of safety for this particulate GC formulation. Our findings support the feasibility of controlling the GC release and optimizing the biological properties of BD-loaded carriers through surface modification paving the way for further tuning and optimization of the pharmaceutical properties of the proposed particulate formulation.</description><subject>Arginine</subject><subject>Biocompatibility</subject><subject>Biological and Medical Physics</subject><subject>Biological properties</subject><subject>Biomaterials</subject><subject>Biophysics</subject><subject>Calcium carbonate</subject><subject>Circuits and Systems</subject><subject>Dextran</subject><subject>Dextran sulfate</subject><subject>Dextrans</subject><subject>Diffusion cells</subject><subject>Diffusion coatings</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Engineering</subject><subject>Glucocorticoids</subject><subject>Immunosuppressive agents</subject><subject>Localization</subject><subject>Nanotechnology</subject><subject>Optimization</subject><subject>Polyelectrolytes</subject><subject>Side effects</subject><subject>Skin diseases</subject><subject>System effectiveness</subject><issn>2191-1630</issn><issn>2191-1649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpFkE1PwzAMhiMEEtPYH-AUiXMhbpImPbLxKU0aQsC1yhp3y7S1XZKBxK8nUAS-2JYe-7VfQs6BXQJj6ipAXhQ6Y7nIGBSaZ_qIjHIoIYNClMd_NWenZBLChqVQrOCaj8j-sX3HEN3KRNe11LSWPuMWTUD65LvGbZEu-uh27nMAms7TNxPRu4jZNGGWzoz3Dn2g887Y1H-4uKZTjGaHcW1C1yK9cb3v-jSfJs_ISWO2ASe_eUxe725fZg_ZfHH_OLueZz1IFTNU0oAFuVzmjDW5zQ0X0pZW2XR3aZemljWvlUBRaoFaaQWmsaaoQdZCSeRjcjHsTdL7Q_qx2nQH3ybJioMAKXheQqL4QIXeu3aF_p8CVn3bWw32Vsne6sfeSvMvZ4lvQQ</recordid><startdate>2025</startdate><enddate>2025</enddate><creator>Demina, Polina A.</creator><creator>Saveleva, Mariia S.</creator><creator>Verkhovskii, Roman A.</creator><creator>Anisimov, Roman A.</creator><creator>Pidenko, Pavel S.</creator><creator>Svenskaya, Yulia I.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope/><orcidid>https://orcid.org/0000-0001-7771-0957</orcidid><orcidid>https://orcid.org/0000-0002-9203-582X</orcidid><orcidid>https://orcid.org/0000-0003-2021-0462</orcidid><orcidid>https://orcid.org/0000-0002-7787-3948</orcidid><orcidid>https://orcid.org/0000-0002-6359-2969</orcidid><orcidid>https://orcid.org/0000-0003-1830-4582</orcidid></search><sort><creationdate>2025</creationdate><title>Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate</title><author>Demina, Polina A. ; Saveleva, Mariia S. ; Verkhovskii, Roman A. ; Anisimov, Roman A. ; Pidenko, Pavel S. ; Svenskaya, Yulia I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p157t-e75a1d15bb200f2d2a345d9d7d3839dbac5c3c74e4984e87871afda6c15c475e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Arginine</topic><topic>Biocompatibility</topic><topic>Biological and Medical Physics</topic><topic>Biological properties</topic><topic>Biomaterials</topic><topic>Biophysics</topic><topic>Calcium carbonate</topic><topic>Circuits and Systems</topic><topic>Dextran</topic><topic>Dextran sulfate</topic><topic>Dextrans</topic><topic>Diffusion cells</topic><topic>Diffusion coatings</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Engineering</topic><topic>Glucocorticoids</topic><topic>Immunosuppressive agents</topic><topic>Localization</topic><topic>Nanotechnology</topic><topic>Optimization</topic><topic>Polyelectrolytes</topic><topic>Side effects</topic><topic>Skin diseases</topic><topic>System effectiveness</topic><toplevel>online_resources</toplevel><creatorcontrib>Demina, Polina A.</creatorcontrib><creatorcontrib>Saveleva, Mariia S.</creatorcontrib><creatorcontrib>Verkhovskii, Roman A.</creatorcontrib><creatorcontrib>Anisimov, Roman A.</creatorcontrib><creatorcontrib>Pidenko, Pavel S.</creatorcontrib><creatorcontrib>Svenskaya, Yulia I.</creatorcontrib><jtitle>BioNanoScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demina, Polina A.</au><au>Saveleva, Mariia S.</au><au>Verkhovskii, Roman A.</au><au>Anisimov, Roman A.</au><au>Pidenko, Pavel S.</au><au>Svenskaya, Yulia I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate</atitle><jtitle>BioNanoScience</jtitle><stitle>BioNanoSci</stitle><date>2025</date><risdate>2025</risdate><volume>15</volume><issue>1</issue><issn>2191-1630</issn><eissn>2191-1649</eissn><abstract>Glucocorticosteroids (GCs) are widely used in the treatment of inflammatory skin diseases due to their anti-inflammatory, anti-proliferative, and immunosuppressive properties. However, long-term therapy with conventional GC formulations can lead to adverse effects, whose severity depends on dosage and duration of treatment. To address these issues, new approaches are being developed to increase the effectiveness of GC treatment and reduce side effects. These include the development of novel delivery systems for targeted drug delivery, efficient localization of GCs at the region of interest, and optimization of the release profile. In this study, we propose a promising system for the topical administration of betamethasone dipropionate (BD), one of the most commonly used GCs. A particulate formulation of this drug, based on micron-sized calcium carbonate (CaCO 3 ) carriers in vaterite form, has been developed. The loading capacity of this formulation was found to be almost 5% (w/w). The release of the drug from the carriers has been studied using a Franz diffusion cell. Surface modification of the BD-CaCO 3 carriers with multilayered polyelectrolyte coatings was performed in an effort to prolong the BD release. Deposition of biocompatible polymers, such as poly-L-arginine hydrochloride and dextran sulfate, was shown to be effective for the release profile optimization. The developed carriers demonstrated sufficient biocompatibility when incubated with L929 fibroblasts in vitro, providing evidence of safety for this particulate GC formulation. Our findings support the feasibility of controlling the GC release and optimizing the biological properties of BD-loaded carriers through surface modification paving the way for further tuning and optimization of the pharmaceutical properties of the proposed particulate formulation.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12668-024-01683-8</doi><orcidid>https://orcid.org/0000-0001-7771-0957</orcidid><orcidid>https://orcid.org/0000-0002-9203-582X</orcidid><orcidid>https://orcid.org/0000-0003-2021-0462</orcidid><orcidid>https://orcid.org/0000-0002-7787-3948</orcidid><orcidid>https://orcid.org/0000-0002-6359-2969</orcidid><orcidid>https://orcid.org/0000-0003-1830-4582</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 2191-1630
ispartof BioNanoScience, 2025, Vol.15 (1)
issn 2191-1630
2191-1649
language eng
recordid cdi_proquest_journals_3141543291
source SpringerLink Journals - AutoHoldings
subjects Arginine
Biocompatibility
Biological and Medical Physics
Biological properties
Biomaterials
Biophysics
Calcium carbonate
Circuits and Systems
Dextran
Dextran sulfate
Dextrans
Diffusion cells
Diffusion coatings
Drug delivery
Drug delivery systems
Engineering
Glucocorticoids
Immunosuppressive agents
Localization
Nanotechnology
Optimization
Polyelectrolytes
Side effects
Skin diseases
System effectiveness
title Investigation and Release Profile Optimization for Vaterite-Based Carriers Loaded with Betamethasone Dipropionate
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A13%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_sprin&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20and%20Release%20Profile%20Optimization%20for%20Vaterite-Based%20Carriers%20Loaded%20with%20Betamethasone%20Dipropionate&rft.jtitle=BioNanoScience&rft.au=Demina,%20Polina%20A.&rft.date=2025&rft.volume=15&rft.issue=1&rft.issn=2191-1630&rft.eissn=2191-1649&rft_id=info:doi/10.1007/s12668-024-01683-8&rft_dat=%3Cproquest_sprin%3E3141543291%3C/proquest_sprin%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3141543291&rft_id=info:pmid/&rfr_iscdi=true