Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial
New interventions are needed for obsessive-compulsive disorder. Here we present a randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing the efficacy of prefrontal cortex stimulation in reducing obsessive-compulsive disorder symptoms and frontostriatal connectiv...
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| Veröffentlicht in: | Nature mental health 2023-08, Vol.1 (8), p.555-563 |
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| creator | Cocchi, Luca Naze, Sebastien Robinson, Conor Webb, Lachlan Sonkusare, Saurabh Hearne, Luke J. Whybird, Genevieve Saffron, Grace Scott, Grace Hall, Caitlin V. Nott, Zoie Adsett, Jessica Grasby, Katrina L. Jentjens, Joshua Scott, James G. Marcus, Leo Savage, Emma Zalesky, Andrew Burgher, Bjorn Breakspear, Michael |
| description | New interventions are needed for obsessive-compulsive disorder. Here we present a randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing the efficacy of prefrontal cortex stimulation in reducing obsessive-compulsive disorder symptoms and frontostriatal connectivity (ACTRN12616001687482). Conducted at a single academic center, the trial enrolled participants diagnosed with obsessive-compulsive disorder who underwent baseline clinical assessments and neuroimaging. The intervention comprised 20 weekday sessions of neuronavigated continuous theta burst stimulation of the frontal pole or sham. Participants and all staff assessing intervention outcomes were blind to the conditions. We enrolled a sample of 50 individuals (26 active continuous theta burst stimulation) who completed the neuroimaging and clinical assessments at the primary 4 week endpoint. Clinical data at the secondary 6 month endpoint were obtained from 46 participants (23 active). Symptoms of obsessive-compulsive disorder (primary outcome) decreased in both groups (active −4.35, P |
| doi_str_mv | 10.1038/s44220-023-00094-0 |
| format | Article |
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Here we present a randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing the efficacy of prefrontal cortex stimulation in reducing obsessive-compulsive disorder symptoms and frontostriatal connectivity (ACTRN12616001687482). Conducted at a single academic center, the trial enrolled participants diagnosed with obsessive-compulsive disorder who underwent baseline clinical assessments and neuroimaging. The intervention comprised 20 weekday sessions of neuronavigated continuous theta burst stimulation of the frontal pole or sham. Participants and all staff assessing intervention outcomes were blind to the conditions. We enrolled a sample of 50 individuals (26 active continuous theta burst stimulation) who completed the neuroimaging and clinical assessments at the primary 4 week endpoint. Clinical data at the secondary 6 month endpoint were obtained from 46 participants (23 active). Symptoms of obsessive-compulsive disorder (primary outcome) decreased in both groups (active −4.35, P < 0.001; sham −5.92, P < 0.001), but there was no significant difference between groups (P = 0.33, ηp2 = 0.02). Likewise, there was no significant difference between groups in changes of frontal pole connectivity with the striatum (P = 0.09, ηp2 = 0.06). Changes in secondary outcomes (symptoms of anxiety and depression and localized frontal pole activity) did not differ between groups. Dropout rates did not vary between groups and the most common treatment-related adverse event in both groups was headache. Our findings suggest that frontal pole continuous theta burst stimulation is no different to sham in reducing obsessive-compulsive disorder symptoms. The absence of changes in brain activity prompts further evaluation of alternative stimulation protocols.Cocchi and coauthors report that continuous theta burst stimulation of the frontal pole shows no difference from sham in reducing symptoms of obsessive-compulsive disorder or frontostriatal connectivity.</description><identifier>ISSN: 2731-6076</identifier><identifier>EISSN: 2731-6076</identifier><identifier>DOI: 10.1038/s44220-023-00094-0</identifier><language>eng</language><publisher>New York City: Nature Publishing Group</publisher><subject>Achievement tests ; Medical imaging ; Neuroimaging ; Transcranial magnetic stimulation</subject><ispartof>Nature mental health, 2023-08, Vol.1 (8), p.555-563</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1640-baf8a9d219a8549cbbefbc88efd78a2b999468d0b01c4a35268acfcc0c99bb793</citedby><cites>FETCH-LOGICAL-c1640-baf8a9d219a8549cbbefbc88efd78a2b999468d0b01c4a35268acfcc0c99bb793</cites><orcidid>0000-0002-0115-0268 ; 0000-0003-4943-3969 ; 0000-0003-3651-2676 ; 0000-0002-5884-7701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3140849022?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,21388,21389,21390,27923,27924,33529,33743,34004,34313,43658,43804,43952,44066,64384,64388,72240,72899,72900,72902</link.rule.ids></links><search><creatorcontrib>Cocchi, Luca</creatorcontrib><creatorcontrib>Naze, Sebastien</creatorcontrib><creatorcontrib>Robinson, Conor</creatorcontrib><creatorcontrib>Webb, Lachlan</creatorcontrib><creatorcontrib>Sonkusare, Saurabh</creatorcontrib><creatorcontrib>Hearne, Luke J.</creatorcontrib><creatorcontrib>Whybird, Genevieve</creatorcontrib><creatorcontrib>Saffron, Grace</creatorcontrib><creatorcontrib>Scott, Grace</creatorcontrib><creatorcontrib>Hall, Caitlin V.</creatorcontrib><creatorcontrib>Nott, Zoie</creatorcontrib><creatorcontrib>Adsett, Jessica</creatorcontrib><creatorcontrib>Grasby, Katrina L.</creatorcontrib><creatorcontrib>Jentjens, Joshua</creatorcontrib><creatorcontrib>Scott, James G.</creatorcontrib><creatorcontrib>Marcus, Leo</creatorcontrib><creatorcontrib>Savage, Emma</creatorcontrib><creatorcontrib>Zalesky, Andrew</creatorcontrib><creatorcontrib>Burgher, Bjorn</creatorcontrib><creatorcontrib>Breakspear, Michael</creatorcontrib><title>Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial</title><title>Nature mental health</title><description>New interventions are needed for obsessive-compulsive disorder. Here we present a randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing the efficacy of prefrontal cortex stimulation in reducing obsessive-compulsive disorder symptoms and frontostriatal connectivity (ACTRN12616001687482). Conducted at a single academic center, the trial enrolled participants diagnosed with obsessive-compulsive disorder who underwent baseline clinical assessments and neuroimaging. The intervention comprised 20 weekday sessions of neuronavigated continuous theta burst stimulation of the frontal pole or sham. Participants and all staff assessing intervention outcomes were blind to the conditions. We enrolled a sample of 50 individuals (26 active continuous theta burst stimulation) who completed the neuroimaging and clinical assessments at the primary 4 week endpoint. Clinical data at the secondary 6 month endpoint were obtained from 46 participants (23 active). Symptoms of obsessive-compulsive disorder (primary outcome) decreased in both groups (active −4.35, P < 0.001; sham −5.92, P < 0.001), but there was no significant difference between groups (P = 0.33, ηp2 = 0.02). Likewise, there was no significant difference between groups in changes of frontal pole connectivity with the striatum (P = 0.09, ηp2 = 0.06). Changes in secondary outcomes (symptoms of anxiety and depression and localized frontal pole activity) did not differ between groups. Dropout rates did not vary between groups and the most common treatment-related adverse event in both groups was headache. Our findings suggest that frontal pole continuous theta burst stimulation is no different to sham in reducing obsessive-compulsive disorder symptoms. 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Here we present a randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing the efficacy of prefrontal cortex stimulation in reducing obsessive-compulsive disorder symptoms and frontostriatal connectivity (ACTRN12616001687482). Conducted at a single academic center, the trial enrolled participants diagnosed with obsessive-compulsive disorder who underwent baseline clinical assessments and neuroimaging. The intervention comprised 20 weekday sessions of neuronavigated continuous theta burst stimulation of the frontal pole or sham. Participants and all staff assessing intervention outcomes were blind to the conditions. We enrolled a sample of 50 individuals (26 active continuous theta burst stimulation) who completed the neuroimaging and clinical assessments at the primary 4 week endpoint. Clinical data at the secondary 6 month endpoint were obtained from 46 participants (23 active). Symptoms of obsessive-compulsive disorder (primary outcome) decreased in both groups (active −4.35, P < 0.001; sham −5.92, P < 0.001), but there was no significant difference between groups (P = 0.33, ηp2 = 0.02). Likewise, there was no significant difference between groups in changes of frontal pole connectivity with the striatum (P = 0.09, ηp2 = 0.06). Changes in secondary outcomes (symptoms of anxiety and depression and localized frontal pole activity) did not differ between groups. Dropout rates did not vary between groups and the most common treatment-related adverse event in both groups was headache. Our findings suggest that frontal pole continuous theta burst stimulation is no different to sham in reducing obsessive-compulsive disorder symptoms. 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| subjects | Achievement tests Medical imaging Neuroimaging Transcranial magnetic stimulation |
| title | Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial |
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