Chitosan Functionalized Skin-Adhesive Formulation for Ergotamine Delivery in Melanoma Treatment

This study develops a skin-penetrating drug delivery system of thiolated chitosan-lithocholic acid nanomicelles for the treatment of melanoma. In this regard, ergotamine was selected as a model drug in consideration of its possible antitumor activities. The resultant system shall not only reduce ser...

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Veröffentlicht in:	BioNanoScience 2025-03, Vol.15 (1), Article 29
Hauptverfasser:	Azhar, Farah, Naureen, Humaira, Shahnaz, Gul, Hamdani, Syed Damin Abbas, Shareef, Usman, Khattak, Shahana, Babar, Mustafeez Mujtaba, Rahdar, Abbas, Fathi-karkan, Sonia, Pandey, Sadanand
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Adhesion tests Animal models Anticancer properties Antitumor activity Biological and Medical Physics Biomaterials Biophysics Cancer Cancer therapies Cell viability Chitosan Circuits and Systems Controlled release Drug delivery Drug delivery systems Engineering Ergotamine In vitro methods and tests In vivo methods and tests Melanoma Nanotechnology Physicochemical properties Side effects Skin tests Tumor microenvironment Tumors
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