Synthesis of bis(indolyl)methanes using N-heterocyclic carbene salt as a C1 precursor

We herein describe an alkylation reaction of indoles with NHC salts to access bis(indolyl)methanes as product. The NHC salt (or free NHC) serves as a C1 precursor due to decomposition of its N-heterocyclic ring. Although the exact roles of zinc powder and acetic/formic acid remain elusive, both of t...

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Veröffentlicht in:	Organic & biomolecular chemistry 2024-11, Vol.22 (46), p.958-962
Hauptverfasser:	Zhou, Bingwei, Gao, Zhao, Yang, Yanhao, Hu, Yuanyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Decomposition reactions Formic acid Indoles Precursors
Online-Zugang:	Volltext
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