High‐Throughput Absorbance‐Activated Droplet Sorting for Engineering Aldehyde Dehydrogenases

Recent decades have seen a dramatic increase in the commercial use of biocatalysts, transitioning from energy‐intensive traditional chemistries to more sustainable methods. Current enzyme engineering techniques, such as directed evolution, require the generation and testing of large mutant libraries...

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Veröffentlicht in:	Angewandte Chemie 2024-12, Vol.136 (49), p.n/a
Hauptverfasser:	Jain, Ankit, Teshima, Mariko, Buryska, Tomas, Romeis, Dennis, Haslbeck, Magdalena, Döring, Manuel, Sieber, Volker, Stavrakis, Stavros, Mello, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbance Aldehyde dehydrogenase Aldehydes Biocatalysts Colorimetry Directed evolution Droplets Enzymes Glyceraldehyde Microfluidics Nicotinamide adenine dinucleotide Screening
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