Conductive molecularly imprinted polymer based on poly(1,8-diaminonaphthalene) decorated on gold nanoparticles for controlled antibiotic release
The combination of conducting polymer and nanogold represents a cutting-edge approach in the development of efficient drug release control systems, particularly leveraging molecular imprinting technology. In this work, a conductive molecularly imprinted polymer (MIP) was electro-synthesized from 1,8...
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| Veröffentlicht in: | Colloid and polymer science 2024-12, Vol.302 (12), p.1881-1890 |
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| container_issue | 12 |
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| container_title | Colloid and polymer science |
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| creator | Trinh, Long Toan Le Nguyen, Huy Nguyen, Mai Tuyet Thi |
| description | The combination of conducting polymer and nanogold represents a cutting-edge approach in the development of efficient drug release control systems, particularly leveraging molecular imprinting technology. In this work, a conductive molecularly imprinted polymer (MIP) was electro-synthesized from 1,8-diaminonaphthalene monomers in the presence of amoxicillin as target molecule on gold nanoparticles (AuNPs). AuNPs play a crucial role in supporting the polymerization process and facilitating the characterization of material properties through various analytical techniques. Furthermore, the conductive MIP facilitates fabrication control through electrochemical parameters, enabling the specific and reversible capture and release of amoxicillin. A comprehensive drug release kinetic study was conducted, revealing a significant departure from the conventional release profile of commercial amoxicillin capsules. While typical capsules release the drug over 1 h, our conductive MIP material demonstrated a substantially prolonged release time, extending up to approximately 8 h. This prolonged-release duration holds promising implications for drug delivery applications, potentially offering improved therapeutic outcomes and patient adherence.
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| doi_str_mv | 10.1007/s00396-024-05314-2 |
| format | Article |
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Graphic Abstract</description><subject>Amoxicillin</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Conducting polymers</subject><subject>Electrochemical analysis</subject><subject>Food Science</subject><subject>Gold</subject><subject>Imprinted polymers</subject><subject>Material properties</subject><subject>Molecular imprinting</subject><subject>Nanoparticles</subject><subject>Nanotechnology and Microengineering</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Soft and Granular Matter</subject><issn>0303-402X</issn><issn>1435-1536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KHTEUx0Ox0KvtC3QVcNOCaU-S-bhZlotWQeimgruQSc7oSCYZk9zCfQsf2egU3Lk6nHP-H_Aj5CuHHxyg_5kBpOoYiIZBK3nDxAey4Y1sGW9ld0Q2IEGyBsTtJ3Kc8wMANKrrNuRpF4Pb2zL9QzpHj3bvTfIHOs1LmkJBR5foDzMmOphctxheD9_42Za5ycxTiMEs9-XeeAz4nTq0MZmyKu-idzSYEBeTymQ9ZjrGRG0MJUXvq8iEMg1TrE-a0GOt-Ew-jsZn_PJ_npCbi_O_u0t2_ef31e7XNbMCoLBx5G0PDY6daFscWtv0clBotsOoJG6VHXgPztmu64RzUhmHSknhBlDWKBjlCTldc5cUH_eYi36I-xRqpZZcCmgk9LKqxKqyKeaccNQVy2zSQXPQL-T1Sl5X8vqVvBbVJFdTfmF4h-kt-h3XM7ojioM</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Trinh, Long Toan</creator><creator>Le Nguyen, Huy</creator><creator>Nguyen, Mai Tuyet Thi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0009-0006-6555-4401</orcidid><orcidid>https://orcid.org/0000-0002-8067-2565</orcidid><orcidid>https://orcid.org/0000-0002-8901-2395</orcidid></search><sort><creationdate>20241201</creationdate><title>Conductive molecularly imprinted polymer based on poly(1,8-diaminonaphthalene) decorated on gold nanoparticles for controlled antibiotic release</title><author>Trinh, Long Toan ; Le Nguyen, Huy ; Nguyen, Mai Tuyet Thi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200t-ff15704ef6255eb5c473b9ea8bf93e89cb170ddc6662dd39ade9932db09ca90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amoxicillin</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Conducting polymers</topic><topic>Electrochemical analysis</topic><topic>Food Science</topic><topic>Gold</topic><topic>Imprinted polymers</topic><topic>Material properties</topic><topic>Molecular imprinting</topic><topic>Nanoparticles</topic><topic>Nanotechnology and Microengineering</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Soft and Granular Matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trinh, Long Toan</creatorcontrib><creatorcontrib>Le Nguyen, Huy</creatorcontrib><creatorcontrib>Nguyen, Mai Tuyet Thi</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Colloid and polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trinh, Long Toan</au><au>Le Nguyen, Huy</au><au>Nguyen, Mai Tuyet Thi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conductive molecularly imprinted polymer based on poly(1,8-diaminonaphthalene) decorated on gold nanoparticles for controlled antibiotic release</atitle><jtitle>Colloid and polymer science</jtitle><stitle>Colloid Polym Sci</stitle><date>2024-12-01</date><risdate>2024</risdate><volume>302</volume><issue>12</issue><spage>1881</spage><epage>1890</epage><pages>1881-1890</pages><issn>0303-402X</issn><eissn>1435-1536</eissn><abstract>The combination of conducting polymer and nanogold represents a cutting-edge approach in the development of efficient drug release control systems, particularly leveraging molecular imprinting technology. In this work, a conductive molecularly imprinted polymer (MIP) was electro-synthesized from 1,8-diaminonaphthalene monomers in the presence of amoxicillin as target molecule on gold nanoparticles (AuNPs). AuNPs play a crucial role in supporting the polymerization process and facilitating the characterization of material properties through various analytical techniques. Furthermore, the conductive MIP facilitates fabrication control through electrochemical parameters, enabling the specific and reversible capture and release of amoxicillin. A comprehensive drug release kinetic study was conducted, revealing a significant departure from the conventional release profile of commercial amoxicillin capsules. While typical capsules release the drug over 1 h, our conductive MIP material demonstrated a substantially prolonged release time, extending up to approximately 8 h. This prolonged-release duration holds promising implications for drug delivery applications, potentially offering improved therapeutic outcomes and patient adherence.
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| subjects | Amoxicillin Characterization and Evaluation of Materials Chemical synthesis Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Conducting polymers Electrochemical analysis Food Science Gold Imprinted polymers Material properties Molecular imprinting Nanoparticles Nanotechnology and Microengineering Physical Chemistry Polymer Sciences Polymers Soft and Granular Matter |
| title | Conductive molecularly imprinted polymer based on poly(1,8-diaminonaphthalene) decorated on gold nanoparticles for controlled antibiotic release |
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