Chitosan‐based spray‐dried solid dispersions of apigenin in a 3D printable drug delivery system
This study aims to develop chitosan‐based apigenin (AGN) spray‐dried solid dispersions (SDSDs) within a 3D pill. AGN SDSDs were prepared using 1:1 (AC1), 1:1.5 (AC2), and 1:2 (AC1) apigenin/chitosan weight ratios. The results of the process yield were found to be (87.5%, 94.2%, and 95.86%) and of dr...
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| Veröffentlicht in: | Journal of applied polymer science 2025-01, Vol.142 (1), p.n/a |
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| creator | Alali, Amer S. Muqtader Ahmed, Mohammed Fatima, Farhat Anwer, Md. Khalid Ibnauf, Mutasim Aboudzadeh, M. Ali |
| description | This study aims to develop chitosan‐based apigenin (AGN) spray‐dried solid dispersions (SDSDs) within a 3D pill. AGN SDSDs were prepared using 1:1 (AC1), 1:1.5 (AC2), and 1:2 (AC1) apigenin/chitosan weight ratios. The results of the process yield were found to be (87.5%, 94.2%, and 95.86%) and of drug assay were obtained as (95.2 ± 1.34%), (99.5 ± 0.85%) and (97.6 ± 2.42%) for AC1, AC2 and AC3, respectively. FTIR revealed compatibility between chitosan and apigenin. DSC and XRD revealed an amorphous state of developed solid dispersions. In contrast, SEM images reflected irregular‐block and near‐spherical‐shape elongated particles in the selected AC2. The antimicrobial examination reflected that AC2 was more effective against Gram‐positive, −negative, and fungal strains. AC2 SDSDs had more antioxidant property compared to pure AGN. The anti‐proliferative activity against A549 lung cancer cell lines showed a better anticancer activity by AC2 SDSDs. Selected AC2 SDSD was filled in a 3D shell pill and was further characterized in terms of stability. The product had a sustained release and similar release profiles after 3 months of storage. The findings suggest that AC2 SDSDs could be a promising candidate for further development as a 3D‐printed drug delivery system for treating multiple disease conditions.
Schematic representation of chitosan‐based apigenin spray‐dried solid dispersions (SDSDs) preparation. |
| doi_str_mv | 10.1002/app.56310 |
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Schematic representation of chitosan‐based apigenin spray‐dried solid dispersions (SDSDs) preparation.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.56310</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>biomaterials ; Chitosan ; differential scanning calorimetry ; Dispersions ; Drug delivery systems ; Image contrast ; polysaccharides ; Shell stability ; Sustained release</subject><ispartof>Journal of applied polymer science, 2025-01, Vol.142 (1), p.n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2220-7a5f136c3b5f3da1fe09a0f65646dfb8beda0ea13aa122916631042d817df6f73</cites><orcidid>0000-0001-8829-8072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.56310$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.56310$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Alali, Amer S.</creatorcontrib><creatorcontrib>Muqtader Ahmed, Mohammed</creatorcontrib><creatorcontrib>Fatima, Farhat</creatorcontrib><creatorcontrib>Anwer, Md. Khalid</creatorcontrib><creatorcontrib>Ibnauf, Mutasim</creatorcontrib><creatorcontrib>Aboudzadeh, M. Ali</creatorcontrib><title>Chitosan‐based spray‐dried solid dispersions of apigenin in a 3D printable drug delivery system</title><title>Journal of applied polymer science</title><description>This study aims to develop chitosan‐based apigenin (AGN) spray‐dried solid dispersions (SDSDs) within a 3D pill. AGN SDSDs were prepared using 1:1 (AC1), 1:1.5 (AC2), and 1:2 (AC1) apigenin/chitosan weight ratios. The results of the process yield were found to be (87.5%, 94.2%, and 95.86%) and of drug assay were obtained as (95.2 ± 1.34%), (99.5 ± 0.85%) and (97.6 ± 2.42%) for AC1, AC2 and AC3, respectively. FTIR revealed compatibility between chitosan and apigenin. DSC and XRD revealed an amorphous state of developed solid dispersions. In contrast, SEM images reflected irregular‐block and near‐spherical‐shape elongated particles in the selected AC2. The antimicrobial examination reflected that AC2 was more effective against Gram‐positive, −negative, and fungal strains. AC2 SDSDs had more antioxidant property compared to pure AGN. The anti‐proliferative activity against A549 lung cancer cell lines showed a better anticancer activity by AC2 SDSDs. Selected AC2 SDSD was filled in a 3D shell pill and was further characterized in terms of stability. The product had a sustained release and similar release profiles after 3 months of storage. The findings suggest that AC2 SDSDs could be a promising candidate for further development as a 3D‐printed drug delivery system for treating multiple disease conditions.
Schematic representation of chitosan‐based apigenin spray‐dried solid dispersions (SDSDs) preparation.</description><subject>biomaterials</subject><subject>Chitosan</subject><subject>differential scanning calorimetry</subject><subject>Dispersions</subject><subject>Drug delivery systems</subject><subject>Image contrast</subject><subject>polysaccharides</subject><subject>Shell stability</subject><subject>Sustained release</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kEtOwzAQhi0EEqWw4AaWWLFI64lrJ1lW5SlVogtYW5PYLq7SJNgpKDuOwBk5CS5lizTS6Nd88_oJuQQ2AcbSKXbdREgO7IiMgBVZMpNpfkxGsQZJXhTilJyFsGEMQDA5ItXi1fVtwOb786vEYDQNncchKu3dXrW101S70BkfXNsE2lqKnVubxjU0BlJ-Qzvvmh7L2lDtd2uqTe3ejR9oGEJvtufkxGIdzMVfHpOXu9vnxUOyfLp_XMyXSZWmKUsyFBa4rHgpLNcI1rACmZVCzqS2ZV4ajcwgcERI0wLk_s1ZqnPItJU242NydZjb-fZtZ0KvNu3ON3Gl4sAh40JIFqnrA1X5NgRvrIrXb9EPCpjae6iih-rXw8hOD-yHq83wP6jmq9Wh4we4TnWE</recordid><startdate>20250105</startdate><enddate>20250105</enddate><creator>Alali, Amer S.</creator><creator>Muqtader Ahmed, Mohammed</creator><creator>Fatima, Farhat</creator><creator>Anwer, Md. Khalid</creator><creator>Ibnauf, Mutasim</creator><creator>Aboudzadeh, M. Ali</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-8829-8072</orcidid></search><sort><creationdate>20250105</creationdate><title>Chitosan‐based spray‐dried solid dispersions of apigenin in a 3D printable drug delivery system</title><author>Alali, Amer S. ; Muqtader Ahmed, Mohammed ; Fatima, Farhat ; Anwer, Md. Khalid ; Ibnauf, Mutasim ; Aboudzadeh, M. Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2220-7a5f136c3b5f3da1fe09a0f65646dfb8beda0ea13aa122916631042d817df6f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>biomaterials</topic><topic>Chitosan</topic><topic>differential scanning calorimetry</topic><topic>Dispersions</topic><topic>Drug delivery systems</topic><topic>Image contrast</topic><topic>polysaccharides</topic><topic>Shell stability</topic><topic>Sustained release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alali, Amer S.</creatorcontrib><creatorcontrib>Muqtader Ahmed, Mohammed</creatorcontrib><creatorcontrib>Fatima, Farhat</creatorcontrib><creatorcontrib>Anwer, Md. Khalid</creatorcontrib><creatorcontrib>Ibnauf, Mutasim</creatorcontrib><creatorcontrib>Aboudzadeh, M. Ali</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alali, Amer S.</au><au>Muqtader Ahmed, Mohammed</au><au>Fatima, Farhat</au><au>Anwer, Md. Khalid</au><au>Ibnauf, Mutasim</au><au>Aboudzadeh, M. Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chitosan‐based spray‐dried solid dispersions of apigenin in a 3D printable drug delivery system</atitle><jtitle>Journal of applied polymer science</jtitle><date>2025-01-05</date><risdate>2025</risdate><volume>142</volume><issue>1</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>This study aims to develop chitosan‐based apigenin (AGN) spray‐dried solid dispersions (SDSDs) within a 3D pill. AGN SDSDs were prepared using 1:1 (AC1), 1:1.5 (AC2), and 1:2 (AC1) apigenin/chitosan weight ratios. The results of the process yield were found to be (87.5%, 94.2%, and 95.86%) and of drug assay were obtained as (95.2 ± 1.34%), (99.5 ± 0.85%) and (97.6 ± 2.42%) for AC1, AC2 and AC3, respectively. FTIR revealed compatibility between chitosan and apigenin. DSC and XRD revealed an amorphous state of developed solid dispersions. In contrast, SEM images reflected irregular‐block and near‐spherical‐shape elongated particles in the selected AC2. The antimicrobial examination reflected that AC2 was more effective against Gram‐positive, −negative, and fungal strains. AC2 SDSDs had more antioxidant property compared to pure AGN. The anti‐proliferative activity against A549 lung cancer cell lines showed a better anticancer activity by AC2 SDSDs. Selected AC2 SDSD was filled in a 3D shell pill and was further characterized in terms of stability. The product had a sustained release and similar release profiles after 3 months of storage. The findings suggest that AC2 SDSDs could be a promising candidate for further development as a 3D‐printed drug delivery system for treating multiple disease conditions.
Schematic representation of chitosan‐based apigenin spray‐dried solid dispersions (SDSDs) preparation.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.56310</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-8829-8072</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | biomaterials Chitosan differential scanning calorimetry Dispersions Drug delivery systems Image contrast polysaccharides Shell stability Sustained release |
| title | Chitosan‐based spray‐dried solid dispersions of apigenin in a 3D printable drug delivery system |
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