Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link Between β-Cell Lipotoxicity and Islet Inflammation

β-Cell lipotoxicity is thought to play an important role in the development of type 2 diabetes. However, no study has examined its role in type 1 diabetes, which could be clinically relevant for slow-onset type 1 diabetes. Reports of enhanced cytokine toxicity in fat-laden islets are consistent with...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-01, Vol.154 (1), p.89-101
Hauptverfasser:	Tang, Christine, Naassan, Anthony E, Chamson-Reig, Astrid, Koulajian, Khajag, Goh, Tracy T, Yoon, Frederick, Oprescu, Andrei I, Ghanim, Husam, Lewis, Gary F, Dandona, Paresh, Donath, Marc Y, Ehses, Jan A, Arany, Edith, Giacca, Adria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Animals Autoimmune diseases Beta cells Biological and medical sciences Cell culture Chemokine CCL2 - blood Cytokines Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes. Impaired glucose tolerance Emulsions - pharmacology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Acids - pharmacology Female Fundamental and applied biological sciences. Psychology Heparin Immunohistochemistry Inflammation Insulin Insulin resistance Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulitis Interleukin-10 - blood Islets of Langerhans - drug effects Islets of Langerhans - immunology Islets of Langerhans - metabolism Lipids Medical sciences Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes mRNA Phospholipids - pharmacology Prediabetic State - immunology Prediabetic State - metabolism Rats Rats, Inbred BB Real-Time Polymerase Chain Reaction Soybean Oil - pharmacology Toxicity Vertebrates: endocrinology
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