17β-Estradiol Activates Glucose Uptake via GLUT4 Translocation and PI3K/Akt Signaling Pathway in MCF-7 Cells

The relationship between estrogen and some types of breast cancer has been clearly established. However, although several studies have demonstrated the relationship between estrogen and glucose uptake via phosphatidylinositol 3-kinase (PI3K)/Akt in other tissues, not too much is known about the poss...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-06, Vol.154 (6), p.1979-1989
Hauptverfasser:	Garrido, Pablo, Morán, Javier, Alonso, Ana, González, Segundo, González, Celestino
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 17β-Estradiol 4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism 4-Chloro-7-nitrobenzofurazan - pharmacokinetics AKT protein Biological and medical sciences Blotting, Western Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell activation Cell Membrane - metabolism Cell proliferation Deoxyglucose - analogs & derivatives Deoxyglucose - metabolism Deoxyglucose - pharmacokinetics Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Estrogens - pharmacology Female Fluorescence Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism Glucose - pharmacokinetics Glucose transporter Glucose Transporter Type 4 - metabolism Humans Kinases Lysates MCF-7 Cells Membranes Phosphatidylinositol 3-Kinase - metabolism Phosphorylation - drug effects Protein Transport - drug effects Proto-Oncogene Proteins c-akt - metabolism Serine - metabolism Sex hormones Signal transduction Signal Transduction - drug effects Translocation Vertebrates: endocrinology
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