Residues K128, 132, and 134 in the Thyroid Hormone Receptor-α Are Essential for Receptor Acetylation and Activity

The thyroid hormone receptor (TR)-α is a nuclear receptor that mediates both transrepression and ligand-dependent transactivation. Here we show that TRα is posttranslationally modified by acetylation in response to its own ligand (T3). Acetylation increases binding to DNA. Using mutagenesis, we iden...

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