Liraglutide, a Long-Acting Human Glucagon-Like Peptide 1 Analog, Improves Glucose Homeostasis in Marginal Mass Islet Transplantation in Mice

The current scarcity of high-quality deceased pancreas donors prevents widespread application of islet transplantation for treatment of labile type 1 diabetes mellitus. Opportunities for the improvement of current techniques include optimization of islet isolation and purification, use of culture wi...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2008-09, Vol.149 (9), p.4322-4328
Hauptverfasser:	Merani, S, Truong, W, Emamaullee, J. A, Toso, C, Knudsen, L. B, Shapiro, A. M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetics Apoptosis Apoptosis - drug effects Beta cells Biological and medical sciences Cell culture Delayed-Action Preparations Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - therapy DNA nucleotidylexotransferase Drug Evaluation, Preclinical Fluorescence microscopy Fundamental and applied biological sciences. Psychology Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide 1 - therapeutic use Glucose Glucose - metabolism Glucose Intolerance - therapy Glucose tolerance Graft rejection Graft Rejection - prevention & control Homeostasis Homeostasis - drug effects Immunological tolerance Insulin Insulin secretion Islet cells Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans Transplantation - methods Islets of Langerhans Transplantation - rehabilitation Liraglutide Mice Mice, Inbred BALB C Pancreas transplantation Pancreatic islet transplantation Peptides Rapamycin Satiety Response - drug effects Streptozocin Syngeneic grafts Tissue culture Transplantation Transplants Transplants & implants Vertebrates: endocrinology
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