Cyclooxygenase-2 and Prostaglandin F2α in Syrian Hamster Leydig Cells: Inhibitory Role on Luteinizing Hormone/Human Chorionic Gonadotropin-Stimulated Testosterone Production

We have previously found that cyclooxygenase-2 (COX-2), a key enzyme in the biosynthesis of prostaglandins (PGs), is present in the testicular interstitial cells of infertile men, whereas it is absent in human testes with no evident morphological changes or abnormalities. To find an animal model for...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2006-09, Vol.147 (9), p.4476-4485
Hauptverfasser:	Frungieri, Mónica B, Gonzalez-Calvar, Silvia I, Parborell, Fernanda, Albrecht, Martin, Mayerhofer, Artur, Calandra, Ricardo S
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - genetics Abnormalities Adult Animal models Animals Biological and medical sciences Biopsy Biosynthesis Chorionic gonadotropin Chorionic Gonadotropin - pharmacology Cricetinae Cyclooxygenase 1 - analysis Cyclooxygenase 2 - analysis Cyclooxygenase 2 - genetics Cyclooxygenase 2 - physiology Cyclooxygenase-1 Cyclooxygenase-2 Dehydrogenase Dehydrogenases Dinoprost - analysis Dinoprost - pharmacology Dinoprost - physiology Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gonadotropins Hamsters Humans Hydroxysteroids Immunohistochemistry Interstitial cells Leydig cells Leydig Cells - chemistry Leydig Cells - drug effects Leydig Cells - metabolism Luteinizing hormone Luteinizing Hormone - pharmacology Male Mesocricetus Phosphoproteins - genetics Pituitary (anterior) Prostaglandin F2a Prostaglandins Proteins Receptors Receptors, Prostaglandin - analysis Receptors, Prostaglandin - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Steroidogenesis Steroidogenic acute regulatory protein Testes Testis - chemistry Testis - enzymology Testosterone Testosterone - biosynthesis Vertebrates: endocrinology
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