Role of Androgens in Fetal Testis Development and Dysgenesis

This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely reduced Sertoli cell number, occurrence of multinucleated gonocytes (MNG), and Leydig cell aggregation. Pregnant rats were a...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-05, Vol.148 (5), p.2027-2036
Hauptverfasser:	Scott, Hayley M, Hutchison, Gary R, Mahood, I. Kim, Hallmark, Nina, Welsh, Michelle, De Gendt, Karel, Verhoeven, Guido, O’Shaughnessy, Peter, Sharpe, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - pharmacology Androgen Antagonists - pharmacology Androgen receptors Androgens Animals Anogenital Anthracene Biological and medical sciences Body Weight Carcinogens - pharmacology Cell aggregation Cell number Dibutyl Phthalate - pharmacology Exposure Female Feminization - pathology Feminization - physiopathology Fetuses Flutamide Flutamide - pharmacology Fundamental and applied biological sciences. Psychology Giant Cells - pathology Gonadal Dysgenesis - pathology Gonadal Dysgenesis - physiopathology Inactivation Leydig Cells - pathology Male Mice Mice, Knockout Organ Size Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Receptors, Androgen - genetics Sertoli Cells - pathology Testes Testis - abnormalities Testis - pathology Testosterone Testosterone - deficiency Testosterone - physiology Testosterone propionate Vertebrates: endocrinology
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