Potent Action of RFamide-Related Peptide-3 on Pituitary Gonadotropes Indicative of a Hypophysiotropic Role in the Negative Regulation of Gonadotropin Secretion

We identified a gene in the ovine hypothalamus encoding for RFamide-related peptide-3 (RFRP-3), and tested the hypothesis that this system produces a hypophysiotropic hormone that inhibits the function of pituitary gonadotropes. The RFRP-3 gene encodes for a peptide that appears identical to human R...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2008-11, Vol.149 (11), p.5811-5821
Hauptverfasser:	Clarke, Iain J, Sari, Ika P, Qi, Yue, Smith, Jeremy T, Parkington, Helena C, Ubuka, Takayoshi, Iqbal, Javed, Li, Qun, Tilbrook, Alan, Morgan, Kevin, Pawson, Adam J, Tsutsui, Kazuyoshi, Millar, Robert P, Bentley, George E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antisera Base Sequence Biological activity Biological and medical sciences Brain - drug effects Brain - metabolism Calcium (intracellular) Calcium - metabolism Calcium mobilization Cloning, Molecular DNA, Complementary - isolation & purification Down-Regulation - drug effects Down-Regulation - genetics Female Follicle Stimulating Hormone - secretion Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Gonadotrophs - drug effects Gonadotrophs - metabolism Gonadotropin-releasing hormone Gonadotropins Gonadotropins - secretion Hypothalamus Luteinizing hormone Luteinizing Hormone - secretion Models, Biological Molecular Sequence Data Neuropeptides - genetics Neuropeptides - pharmacology Neuropeptides - physiology Paraventricular nucleus Peptides Pituitary (anterior) Pituitary gland Pituitary Hormone-Releasing Hormones - genetics Pituitary Hormone-Releasing Hormones - pharmacology Pituitary Hormone-Releasing Hormones - physiology Secretion Sheep - genetics Sheep - metabolism Vertebrates: endocrinology
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