Differential Regulation of Cell Migration and Proliferation through Proline-Rich Tyrosine Kinase 2 in Endothelial Cells

Proline-rich tyrosine kinase 2 (Pyk2), a member of the focal adhesion kinase family, is thought to act as a key component in vasculogenesis and angiogenesis. Therefore, we studied the effect of mutant Pyk2 expression on the migration and proliferation in endothelial cells (ECs). Two types of mutant...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-07, Vol.145 (7), p.3324-3330
Hauptverfasser:	Kuwabara, Koichiro, Nakaoka, Takashi, Sato, Kaori, Nishishita, Toshihide, Sasaki, Terukatsu, Yamashita, Naohide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Angiogenesis Biological and medical sciences Cell adhesion & migration Cell Division - physiology Cell migration Cell Movement - physiology Cell proliferation Cells, Cultured Crk-Associated Substrate Protein Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - enzymology Expression vectors Focal adhesion kinase Focal Adhesion Kinase 2 Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Humans Infections Kinases Multiplicity of infection Mutagenesis Mutants Neovascularization, Physiologic - physiology Phosphorylation Proline Proline-rich tyrosine kinase 2 Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins - metabolism Retinoblastoma-Like Protein p130 Signal Transduction - physiology Tyrosine Tyrosine - metabolism Umbilical Veins Vertebrates: endocrinology Western blotting
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