Oxytocin Receptor Is Expressed in the Penis and Mediates an Estrogen-Dependent Smooth Muscle Contractility

Oxytocin (OT) is released by the posterior pituitary during male orgasm and is supposed to participate in the ejaculatory process. We now report evidence demonstrating the presence of an OT receptor gene (real-time RT-PCR and Northern blot) and protein (immunohistochemistry, Western blot, and bindin...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-04, Vol.145 (4), p.1823-1834
Hauptverfasser:	Vignozzi, Linda, Filippi, Sandra, Luconi, Michaela, Morelli, Annamaria, Mancina, Rosa, Marini, Mirca, Vannelli, Gabriella Barbara, Granchi, Simone, Orlando, Claudio, Gelmini, Stefania, Ledda, Fabrizio, Forti, Gianni, Maggi, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Antiestrogens Aromatase Aromatase Inhibitors Biological and medical sciences Enzyme Inhibitors - pharmacology Estradiol - pharmacology Estrogen Antagonists - pharmacology Estrogen receptors Estrogens Estrogens - physiology Fundamental and applied biological sciences. Psychology Genital tract Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - agonists Hormones Humans Hypogonadism Hypogonadism - chemically induced Hypogonadism - physiopathology Immunohistochemistry In Vitro Techniques Male Males Muscle contraction Muscle Contraction - physiology Muscle, Smooth - physiology Nitriles - pharmacology Osmolar Concentration Oxytocin Oxytocin - pharmacology Penis Penis - metabolism Penis - physiology Pituitary (posterior) Rabbits Real time Receptors Receptors, Oxytocin - metabolism Sex hormones Smooth muscle Tamoxifen - pharmacology Testosterone Triazoles - pharmacology Triptorelin Pamoate - analogs & derivatives Vertebrates: endocrinology
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