An Exonic Splicing Enhancer in Human IGF-I Pre-mRNA Mediates Recognition of Alternative Exon 5 by the Serine-Arginine Protein Splicing Factor-2/ Alternative Splicing Factor

The human IGF-I gene has six exons, four of which are alternatively spliced. Variations in splicing involving exon 5 may occur, depending on the tissue type and hormonal environment. To study the regulation of splicing to IGF-I exon 5, we established an in vitro splicing assay, using a model pre-mRN...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2002-01, Vol.143 (1), p.146-154
Hauptverfasser:	Smith, Philip J, Spurrell, Emma L, Coakley, John, Hinds, Charles J, Ross, Richard J. M, Krainer, Adrian R, Chew, Shern L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Deletion mutant Exons Gene deletion Insulin-like growth factor I mRNA Nucleotides Proteins Serine Splicing factors
Online-Zugang:	Volltext
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