Epidermal Growth Factor Increases Cortisol Production and Type II 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-Isomerase Expression in Human Adrenocortical Carcinoma Cells: Evidence for a Stat5-Dependent Mechanism

We tested the ability of epidermal growth factor (EGF) to regulate a key enzyme in the adrenal synthesis of glucocorticoids: human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3βHSD). EGF treatment (25 ng/ml) of human adrenocortical carcinoma cells (H295R) resulted in a 5-fold increase i...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-05, Vol.144 (5), p.1847-1853
Hauptverfasser:	Feltus, F. Alex, Kovacs, William J, Nicholson, Wendell, Silva, Corrine M, Nagdas, Subir K, Ducharme, Nicole A, Melner, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Carcinoma Cortisol Dehydrogenase Dehydrogenases Enzymes Epidermal growth factor Glucocorticoids Growth factors Hormones Hydroxysteroids Isoforms Molecular modelling Nucleotide sequence Nucleotides Point mutation Regulatory sequences Reporter gene Stat5 protein
Online-Zugang:	Volltext
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