Growth Hormone-Deficient Dwarf Animals Are Resistant to Dimethylbenzanthracine (DMBA)-Induced Mammary Carcinogenesis

Increased plasma IGF-1 has consistently been associated with a variety of human cancers, whereas reduced levels of IGF-1 are associated with increased lifespan in other species. However, the aforementioned relationships are correlational or are derived from animal models that are not specific for gr...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2002-10, Vol.143 (10), p.4139-4142
Hauptverfasser:	Ramsey, Melinda M, Ingram, Rhonda L, Cashion, Adrienne B, Ng, Amy H, Cline, J. Mark, Parlow, A. F, Sonntag, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Animal models Animals Body weight Carcinogenesis Carcinogens Dwarfism - genetics Dwarfism - immunology Dwarfism - metabolism Female Growth Hormone - deficiency Growth hormones Heterozygote Immunity, Innate Insulin-like growth factor I Insulin-Like Growth Factor I - deficiency Insulin-like growth factors Life span Mammary Neoplasms, Experimental - chemically induced Physiological effects Plasma levels Rats Rats, Inbred Lew Reference Values Tumors
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