Induction of Reproductive Tract Developmental Abnormalities in the Male Rat by Lowering Androgen Production or Action in Combination with a Low Dose of Diethylstilbestrol: Evidence for Importance of the Androgen-Estrogen Balance

This study tested the hypothesis that testis/reproductive tract abnormalities induced in the rat by neonatal treatment with diethylstilbestrol (DES) result from disturbance of the androgen-estrogen balance. Male rats were treated neonatally with a dose of DES (0.1 μg) that induced either no or small...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2002-12, Vol.143 (12), p.4797-4808
Hauptverfasser:	Rivas, Ana, Fisher, Jane S, McKinnell, Chris, Atanassova, Nina, Sharpe, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Androgen Antagonists - pharmacology Androgen receptors Androgens Androgens - physiology Animals Animals, Newborn - growth & development Bisphenol A Cell Size Combined treatment Diethylstilbestrol Diethylstilbestrol - administration & dosage Distension Ducts Epithelial cells Epithelial Cells - cytology Epithelium Estrogen Receptor alpha Estrogens Estrogens - physiology Flutamide Flutamide - pharmacology Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - antagonists & inhibitors Male Males Neonates Parameter sensitivity Rats Rats, Wistar Receptors Receptors, Androgen - analysis Receptors, Estrogen - analysis Reproduction - physiology Reproductive system Testis - cytology Testis - drug effects Testis - growth & development Testosterone Testosterone - blood Vas deferens Vas Deferens - cytology Vas Deferens - drug effects Vas Deferens - growth & development
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!