Testosterone (T) Enhances Apoptosis-Related Damage in Human Vascular Endothelial Cells

Androgens may contribute to higher cardiovascular risk in men via deleterious effects on vascular endothelial cells (EC). We examined the effects of androgens on male human umbilical vein EC (EA.hy926) in culture. [3H]Thymidine incorporation assays showed that after 24-h serum deprivation, testoster...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2002-03, Vol.143 (3), p.1119-1125
Hauptverfasser:	Ling, Shanhong, Dai, Aozhi, Williams, Maro R. I, Myles, Kathy, Dilley, Rodney J, Komesaroff, Paul A, Sudhir, Krishnankutty
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Annexin V Apoptosis Bcl-2 protein Cardiovascular diseases Cell culture Culture Damage detection Damage patterns Dehydroepiandrosterone Deoxyribonucleic acid Deprivation DNA DNA biosynthesis DNA damage Endothelial cells Fluorescein isothiocyanate Flutamide Gels Gene expression Health risks Iodides Leukemia Lymphoma Propidium iodide Synthesis Testosterone Thymidine Umbilical vein Western blotting
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