Parathyroid Hormone-Related Peptide Interacts with Bone Morphogenetic Protein 2 to Increase Osteoblastogenesis and Decrease Adipogenesis in Pluripotent C3H10T½ Mesenchymal Cells

We examined the effect of PTH-related peptide (PTHrP) on modulating adipogenesis and osteoblastogenesis in the pluripotent mesenchymal cell line C3H10T½. These cells express the type 1 PTH/PTHrP receptor, thereby allowing PTHrP to inhibit bone morphogenetic protein 2 (BMP2) from enhancing gene expre...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2003-12, Vol.144 (12), p.5511-5520
Hauptverfasser:	Chan, George K, Miao, Dengshun, Deckelbaum, Ron, Bolivar, Isabel, Karaplis, Andrew, Goltzman, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Alkaline phosphatase Bone morphogenetic protein 2 Collagen (type I) Gene expression Kinases Lipids Mesenchyme Osteoblastogenesis Osteoblasts Osteocalcin Parathyroid hormone Parathyroid hormone-related protein Peptides Peroxisome proliferator-activated receptors Phenotypes Pluripotency Protein kinase C Proteins Receptors Stimulators
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