Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice

Abstract Intracerebroventricular injection of CRF or urocortin (Ucn) reduces appetite and body weight. CRFR1 and CRFR2, the receptors for CRF and Ucn, are expressed in neurons associated with appetite-control and metabolism, but their relative contributions in mediating CRF- or Ucn-induced hypophagi...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2000-08, Vol.141 (8), p.2715-2724
Hauptverfasser:	Bradbury, Margaret J., McBurnie, Mary I., Denton, Derek A., Lee, Kuo-Fen, Vale, Wylie W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Appetite Body weight Body weight loss Corticosterone Corticotropin-releasing hormone Diurnal variations Drinking water Food Food intake Genotypes Glucocorticoids Homeostasis Hypophagia Injection Intracerebroventricular administration Receptors Urocortin Weight loss Weight reduction
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